Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:236310
This model achieves electrotonic transform and computes mean inward and outward attenuation from 0 to 500 Hz input; and randomly activates synapses along dendrites to simulate AMPAR mediated EPSCs. For electrotonic analysis, in Elec folder, the entry file is MSNelec_transform.hoc. For EPSC simulation, in Syn folder, the entry file is randomepsc.hoc. Run read_EPSCsims_mdb_alone.m next with the simulated parameter values specified to compute the mean EPSC.
Reference:
1 . Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI (2018) Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One 13:e0200626 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Membrane Properties; Electrotonus; Synaptic-input statistic;
Implementer(s):
Search NeuronDB for information about:  AMPA;
/
GoodliffeEtAl2018
Syn
tau_tables
bkkca.mod
cadyn.mod *
caL.mod
caL13.mod
caldyn.mod
can.mod
caq.mod *
car.mod
cat.mod
kaf.mod
kas.mod
kdr.mod
kir.mod *
krp.mod *
linearIclamp.mod
naf.mod
nap.mod
skkca.mod
stim.mod *
actionPotentialPlayer.hoc *
all_tau_vecs.hoc
analyticFunctions.hoc *
analyze_EPSC.m
aux_procs.hoc
baseline_values.txt
basic_procs.hoc
createFit_WTD1.m
electro_procs.hoc
fixnseg.hoc *
load_scripts.hoc
msp_template.hoc
PFC-V1_AddSynapses.hoc
PFC-V1_AddSynapses_fix.hoc
PFC-V1_AddSynapses_neg.hoc
PFC-V1_AddSynapses_negexp.hoc
plot_seClamp_i.ses
ran_test.hoc
randomepsc.hoc
ranstream.hoc
read_EPSCsims_mdb_alone.m
readcell.hoc
readNRNbin_Vclamp.m
                            
TITLE Nahc - Fast sodium current for nucleus accumbens (from hippocampal pyramidal cell)

COMMENT
Martina M, Jonas P (1997). "Functional differences in na+ channel gating between fast-
spiking interneurons and principal neurons of rat hippocampus." J Phys, 505(3): 593-603.

recorded at 22C - Q10 of 3 to convert to 35C

Jason Moyer 2004 - jtmoyer@seas.upenn.edu

ENDCOMMENT

UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
        (S)  = (siemens)
}
 
NEURON {
        SUFFIX naf
        USEION na READ ena WRITE ina
        RANGE  gnabar, ina, mshift, hshift
}
 
PARAMETER {
    gnabar   =   3 	(S/cm2)	: 1.5 in soma, 0.0195 in all dends

	mvhalf = -23.9		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	mslope = -11.8		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	mshift = 6.6594		(mV)	: 

	hvhalf = -62.9		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	hslope = 10.7		(mV)	: Martina/Jonas 1997 Table 1 (Pyr. cells)
	hshift = 0.52039		(mV)	: 

	mqfact = 2.16
	hqfact = 1.2	
}
 
STATE { m h }
 
ASSIGNED {
		ena				(mV)
        v 				(mV)
        ina 				(mA/cm2)
        gna				(S/cm2)
        minf 
	hinf
}
 
BREAKPOINT {
        SOLVE state METHOD cnexp
        gna = gnabar * m * m * m  * h
        ina = gna * ( v - ena )
}
 
 
INITIAL {
	rates(v)
	
	m = minf
	h = hinf
}

FUNCTION_TABLE taumnaf (v(mV))  (ms)	: Martina/Jonas 1997 Fig 2E
FUNCTION_TABLE tauhnaf (v(mV))  (ms)	: Martina/Jonas 1997 Fig 4C

DERIVATIVE state { 
        rates(v)
        m' = (minf - m) / (taumnaf(v)/mqfact)
        h' = (hinf - h) / (tauhnaf(v)/hqfact)
}
 
PROCEDURE rates(v (mV)) {  
	TABLE minf, hinf DEPEND mshift, hshift, mslope, hslope
		FROM -200 TO 200 WITH 201
			minf = 1 / (1 + exp( (v-mvhalf-mshift) / mslope ) ) 
		    hinf = 1 / (1 + exp( (v-hvhalf-hshift) / hslope ) )
}
 
 

Loading data, please wait...