Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)

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Accession:236310
This model achieves electrotonic transform and computes mean inward and outward attenuation from 0 to 500 Hz input; and randomly activates synapses along dendrites to simulate AMPAR mediated EPSCs. For electrotonic analysis, in Elec folder, the entry file is MSNelec_transform.hoc. For EPSC simulation, in Syn folder, the entry file is randomepsc.hoc. Run read_EPSCsims_mdb_alone.m next with the simulated parameter values specified to compute the mean EPSC.
Reference:
1 . Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI (2018) Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One 13:e0200626 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum spiny neuron;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Membrane Properties; Electrotonus; Synaptic-input statistic;
Implementer(s):
Search NeuronDB for information about:  AMPA;
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GoodliffeEtAl2018
Elec
tau_tables
tauh_car.txt *
tauh_cat.txt *
tauh_kas.txt *
tauh_krp.txt *
tauh_naf.txt *
tauh_nap.txt *
taum_cat.txt *
taum_kaf.txt *
taum_kas.txt *
taum_kir.txt *
taum_krp.txt *
taum_naf.txt *
vtau_car.txt *
vtau_cat.txt *
vtau_kaf.txt *
vtau_kas.txt *
vtau_kir.txt *
vtau_krp.txt *
vtau_naf.txt *
vtau_nap.txt *
                            
500
500
500
500
500
500
500
500
550
686.64
1000
1595.8
2250
2691.6
2900
2957.5
2900
2760.6
2600
2443.6
2250
2001.2
1800
1734.4
1750
1756.3
1750
1748.4
1750
1750.6

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