SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:237469
" … Here, using computational modeling, we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in the delta frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V pyramidal cell network gain and response to delta-frequency oscillations may also cause a decit in a single-cell correlate of the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia."
Reference:
1 . Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, Ness TV, Moberget T, Elvsåshagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT (2019) Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations. Cereb Cortex 29:875-891 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): Ca pump; I A, slow; I h; I K; I K,Ca; I K,leak; I L high threshold; I M; I Na,p; I Na,t; I T low threshold;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; NMDA; Gaba;
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav3.3 CACNA1I; HCN1; Kv2.1 KCNB1; Nav1.1 SCN1A; PMCA ATP2B2;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON; Python; LFPy;
Model Concept(s): Schizophrenia; Oscillations;
Implementer(s): Maki-Marttunen, Tuomo [tuomo.maki-marttunen at tut.fi];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; AMPA; NMDA; Gaba; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I K,leak; I M; I h; I K,Ca; I A, slow; Ca pump; Gaba; Glutamate;
/
scznet
approxhaynet
models
README.html
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
ProbAMPANMDA2.mod
ProbAMPANMDA2group.mod
ProbAMPANMDA2groupdet.mod
ProbUDFsyn2.mod
ProbUDFsyn2group.mod
ProbUDFsyn2groupdet.mod
SK_E2.mod *
SKv3_1.mod *
approxhaynetstuff.py
calcEEG.py
calcEEG_uncombined.py
calcmutgains.py
calcmutgains_comb.py
calcmutoscs.py
calcmutoscs_comb.py
calcspectra.py
calcspectra_comb.py
combinemutgains_parallel.py
combinemutgains_parallel_comb.py
combinemutgains_parallel_withLFP.py
combinemutoscs_parallel.py
combinemutoscs_parallel_comb.py
drawfig1ab.py
drawfig1c.py
drawfig2ab.py
drawfig2c.py
drawstationary_EEG.py
drawstationary_EEG_pop.py
mutation_stuff.py *
mytools.py
pars_withmids_combfs_final.sav *
runmanycellsLFP.py
runsinglecellLFP.py
saveisidists.py
savespikesshufflephases.py
scalings_cs.sav
simosc_parallel.py
simosc_parallel_comb_varconn.py
simseedburst_func.py
simseedburst_func_comb_varconn.py
simseedburst_func_withLFP.py
simseedburst_func_withLFP.pyc
                            
(lp0
(lp1
(lp2
(lp3
(lp4
F0.0936880111694336
aa(lp5
F0.060378074645996094
aa(lp6
F0.06109142303466797
aF0.14075374603271484
aF0.07094478607177734
aF0.10736560821533203
aF0.043656349182128906
aF0.6925745010375977
aF0.04821300506591797
aF0.3592519760131836
aF0.08166790008544922
aF0.08142566680908203
aF0.10337543487548828
aF0.06806468963623047
aF0.053833961486816406
aF0.2188272476196289
aF0.060975074768066406
aF0.14244747161865234
aa(lp7
F0.04004383087158203
aF0.17981243133544922
aF0.05029582977294922
aF0.09127521514892578
aa(lp8
F0.0749368667602539
aF0.1067514419555664
aF0.08142948150634766
aF0.0956583023071289
aF0.059355735778808594
aF0.20083332061767578
aF0.06319522857666016
aF0.16378498077392578
aa(lp9
F0.22682476043701172
aF0.32930850982666016
aaa(lp10
(lp11
F0.6136331558227539
aa(lp12
F1.9999990463256836
aa(lp13
F0.3222665786743164
aF0.41141223907470703
aF0.21189212799072266
aF1.1010618209838867
aF0.8140974044799805
aF0.1455087661743164
aF0.5170698165893555
aF0.20410823822021484
aF0.28528690338134766
aF0.5108041763305664
aF0.19719791412353516
aF1.686711311340332
aF0.7073202133178711
aF0.1555471420288086
aF0.4600229263305664
aF0.2178792953491211
aa(lp14
F1.9999990463256836
aaa(lp15
(lp16
F0.11794757843017578
aF0.1064138412475586
aa(lp17
F0.11466693878173828
aF1.9621381759643555
aF0.13500690460205078
aF0.9052286148071289
aF0.10362720489501953
aF0.6788167953491211
aF0.11969470977783203
aF1.116511344909668
aa(lp18
F0.28152942657470703
aF0.17797183990478516
aF0.3024568557739258
aF0.1878061294555664
aa(lp19
F0.23220157623291016
aa(lp20
F0.0639333724975586
aF0.4413747787475586
aF0.07548999786376953
aF0.2175302505493164
aF0.08444499969482422
aF0.1463632583618164
aF0.1065664291381836
aF0.10571002960205078
aa(lp21
F0.09231853485107422
aF0.0908193588256836
aaa(lp22
(lp23
F1.9999990463256836
aF1.9999990463256836
aa(lp24
F0.9677743911743164
aF1.9999990463256836
aaa(lp25
(lp26
F0.9832143783569336
aa(lp27
F0.047995567321777344
aa(lp28
F0.17417621612548828
aaa(lp29
(lp30
F0.2241373062133789
aaa(lp31
(lp32
F0.2306222915649414
aa(lp33
F0.21791744232177734
aa(lp34
F0.10474109649658203
aa(lp35
F1.6251230239868164
aaa(lp36
(lp37
F0.12438488006591797
aaa(lp38
(lp39
F0.049078941345214844
aa(lp40
F0.0626688003540039
aa(lp41
F0.27309513092041016
aa(lp42
F0.037331581115722656
aa(lp43
F0.12926959991455078
aa(lp44
F0.06197834014892578
aaa(lp45
(lp46
F1.9999990463256836
aa(lp47
F0.019499778747558594
aa(lp48
F0.03123188018798828
aa(lp49
F0.03818035125732422
aaa(lp50
(lp51
F1.9999990463256836
aaa(lp52
(lp53
F1.880894660949707
aa(lp54
F0.5243196487426758
aaa(lp55
(lp56
F0.29638195037841797
aa(lp57
F0.2819528579711914
aF0.8071088790893555
aa(lp58
F1.2257013320922852
aaa(lp59
(lp60
F1.9999990463256836
aa(lp61
F1.9999990463256836
aa(lp62
F1.9999990463256836
aa(lp63
F1.9999990463256836
aa(lp64
F1.9999990463256836
aa(lp65
F1.9999990463256836
aaa(lp66
(lp67
F0.5664091110229492
aa(lp68
F0.34342098236083984
aa(lp69
F0.3402414321899414
aaaa(lp70
(lp71
(lp72
F0.08977603912353516
aa(lp73
F0.059327125549316406
aa(lp74
F0.059845924377441406
aF0.13706684112548828
aF0.07228374481201172
aF0.10247135162353516
aF0.04250621795654297
aF0.6562566757202148
aF0.047196388244628906
aF0.2998056411743164
aF0.0773935317993164
aF0.07892513275146484
aF0.10052204132080078
aF0.0656290054321289
aF0.055907249450683594
aF0.20419025421142578
aF0.05981922149658203
aF0.12634944915771484
aa(lp75
F0.041131019592285156
a(lp76
aF0.04972362518310547
aF0.08105182647705078
aa(lp77
F0.0736989974975586
aF0.10406970977783203
aF0.08191776275634766
aF0.09278202056884766
aF0.05828380584716797
aF0.18516063690185547
aF0.062247276306152344
aF0.1464834213256836
aa(lp78
F0.22818851470947266
aF0.31713008880615234
aaa(lp79
(lp80
F0.5984888076782227
aa(lp81
F1.9999990463256836
aa(lp82
F0.32312870025634766
aF0.34284305572509766
aF0.21057987213134766
aF0.6863679885864258
aF0.6640443801879883
aF0.1426553726196289
aF0.4317140579223633
aF0.2004404067993164
aF0.2886781692504883
aF0.3925771713256836
aF0.19584941864013672
aF0.9765634536743164
aF0.5876779556274414
aF0.1525430679321289
aF0.4024991989135742
aF0.2181539535522461
aa(lp83
F1.9999990463256836
aaa(lp84
(lp85
F0.1207876205444336
aF0.10999774932861328
aa(lp86
F0.11852169036865234
aF1.9999990463256836
aF0.1423177719116211
aF0.7865991592407227
aF0.1010427474975586
aF0.6381750106811523
aF0.1170949935913086
aF0.9971685409545898
aa(lp87
(lp88
aF0.16098690032958984
aF0.2920522689819336
aF0.16771411895751953
aa(lp89
F0.21364307403564453
aa(lp90
F0.06517314910888672
aF0.4407796859741211
aF0.07906436920166016
aF0.2073221206665039
aF0.08178424835205078
aF0.1426534652709961
aF0.1098623275756836
aF0.10181331634521484
aa(lp91
F0.09562397003173828
aF0.09415149688720703
aaa(lp92
(lp93
F1.9999990463256836
aF1.9999990463256836
aa(lp94
F0.7265634536743164
aF1.0903444290161133
aaa(lp95
(lp96
F1.0244131088256836
aa(lp97
F0.05009174346923828
aa(lp98
F0.16877460479736328
aaa(lp99
(lp100
F0.2119455337524414
aaa(lp101
(lp102
F0.2355508804321289
aa(lp103
F0.2295236587524414
aa(lp104
F0.1069803237915039
aa(lp105
F1.6853876113891602
aaa(lp106
(lp107
F0.11770153045654297
aaa(lp108
(lp109
F0.051451683044433594
aa(lp110
F0.0662546157836914
aa(lp111
F0.10095882415771484
aa(lp112
F0.024291038513183594
aa(lp113
F0.1377267837524414
aa(lp114
F0.06394481658935547
aaa(lp115
(lp116
F1.9999990463256836
aa(lp117
F0.018210411071777344
aa(lp118
F0.02824687957763672
aa(lp119
F0.03076457977294922
aaa(lp120
(lp121
F1.9999990463256836
aaa(lp122
(lp123
F1.9999990463256836
aa(lp124
F0.5563154220581055
aaa(lp125
(lp126
F0.22623538970947266
aa(lp127
F0.21613597869873047
aF0.9159402847290039
aa(lp128
F1.9999990463256836
aaa(lp129
(lp130
F1.9999990463256836
aa(lp131
F1.9999990463256836
aa(lp132
F1.9999990463256836
aa(lp133
F1.9999990463256836
aa(lp134
F1.9999990463256836
aa(lp135
F1.9999990463256836
aaa(lp136
(lp137
F0.5162267684936523
aa(lp138
F0.34560298919677734
aa(lp139
F0.34199047088623047
aaaaa(lp140
(lp141
(lp142
(lp143
S'offma_Ca_HVA'
p144
aS'offmb_Ca_HVA'
p145
aa(lp146
S'offha_Ca_HVA'
p147
aS'offhb_Ca_HVA'
p148
aaaa(lp149
(lp150
(lp151
g144
ag145
aa(lp152
g147
ag148
aaaa(lp153
(lp154
(lp155
g144
ag145
aa(lp156
S'sloma_Ca_HVA'
p157
aS'slomb_Ca_HVA'
p158
aa(lp159
g147
ag148
aa(lp160
S'sloha_Ca_HVA'
p161
aS'slohb_Ca_HVA'
p162
aaag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
ag154
aa(lp163
(lp164
(lp165
g144
ag145
aa(lp166
g157
ag158
aaag164
ag164
ag164
aa(lp167
(lp168
(lp169
g144
ag145
aa(lp170
g157
ag158
aa(lp171
g147
ag148
aaag168
ag168
ag168
ag168
ag168
ag168
ag168
aa(lp172
(lp173
(lp174
g144
ag145
aa(lp175
g147
ag148
aa(lp176
g161
ag162
aaag173
aa(lp177
(lp178
(lp179
g147
ag148
aa(lp180
g161
ag162
aaaa(lp181
(lp182
(lp183
S'tauha_Ca_HVA'
p184
aS'tauhb_Ca_HVA'
p185
aaaa(lp186
(lp187
(lp188
g144
ag145
aa(lp189
g147
ag148
aa(lp190
S'tauma_Ca_HVA'
p191
aS'taumb_Ca_HVA'
p192
aa(lp193
g184
ag185
aaag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
ag187
aa(lp194
(lp195
(lp196
g184
ag185
aaaa(lp197
(lp198
(lp199
g144
ag145
aa(lp200
g157
ag158
aa(lp201
g147
ag148
aa(lp202
g161
ag162
aa(lp203
g184
ag185
aaag198
aa(lp204
(lp205
(lp206
g144
ag145
aa(lp207
g157
ag158
aa(lp208
g147
ag148
aa(lp209
g161
ag162
aa(lp210
g184
ag185
aaag205
ag205
ag205
ag205
ag205
ag205
ag205
aa(lp211
(lp212
(lp213
g144
ag145
aa(lp214
g157
ag158
aa(lp215
g184
ag185
aaag212
ag212
ag212
aa(lp216
(lp217
(lp218
g144
ag145
aa(lp219
g157
ag158
aa(lp220
g147
ag148
aa(lp221
g161
ag162
aaaa(lp222
(lp223
(lp224
g144
ag145
aa(lp225
g157
ag158
aa(lp226
g147
ag148
aa(lp227
g161
ag162
aa(lp228
g184
ag185
aaag223
ag223
ag223
ag223
ag223
ag223
ag223
aa(lp229
(lp230
(lp231
g144
ag145
aa(lp232
g157
ag158
aa(lp233
g184
ag185
aaag230
aa(lp234
(lp235
S'offma_Ca_LVAst'
p236
aS'offha_Ca_LVAst'
p237
a(lp238
S'taummin_Ca_LVAst'
p239
aS'taumdiff_Ca_LVAst'
p240
aa(lp241
S'tauhmin_Ca_LVAst'
p242
aS'tauhdiff_Ca_LVAst'
p243
aaag235
aa(lp244
(lp245
g236
aS'sloma_Ca_LVAst'
p246
ag237
aS'sloha_Ca_LVAst'
p247
a(lp248
g239
ag240
aa(lp249
g242
ag243
aaag245
aa(lp250
(lp251
(lp252
g191
ag192
aaaa(lp253
(lp254
(lp255
g144
ag145
aa(lp256
g157
ag158
aa(lp257
g191
ag192
aaaa(lp258
(lp259
(lp260
g144
ag145
aa(lp261
g157
ag158
aa(lp262
g147
ag148
aa(lp263
g161
ag162
aaaa(lp264
(lp265
S'gamma_CaDynamics_E2'
p266
aaa(lp267
(lp268
S'decay_CaDynamics_E2'
p269
aaa(lp270
(lp271
g269
aS'minCai_CaDynamics_E2'
p272
aaa(lp273
(lp274
g269
aaa(lp275
(lp276
g272
aaa(lp277
(lp278
g266
aaa(lp279
(lp280
S'offm_NaTa_t'
p281
aS'offh_NaTa_t'
p282
aS'slom_NaTa_t'
p283
aS'sloh_NaTa_t'
p284
aaa(lp285
(lp286
g281
ag282
ag283
ag284
aaa(lp287
(lp288
g281
ag282
ag283
ag284
a(lp289
S'tauha_NaTa_t'
p290
aS'tauhb_NaTa_t'
p291
aaaa(lp292
(lp293
g281
ag282
ag283
ag284
a(lp294
g290
ag291
aaaa(lp295
(lp296
g281
ag283
a(lp297
g290
ag291
aaaa(lp298
(lp299
g281
ag282
ag283
ag284
aaa(lp300
(lp301
(lp302
S'offh_Nap_Et2'
p303
aS'offha_Nap_Et2'
p304
aS'offhb_Nap_Et2'
p305
aaaa(lp306
(lp307
(lp308
g303
ag304
ag305
aaS'sloh_Nap_Et2'
p309
ag281
ag282
ag284
aaa(lp310
(lp311
g281
ag282
aaa(lp312
(lp313
g281
ag282
aaa(lp314
(lp315
(lp316
S'taummin_K_Pst'
p317
aS'taumdiff1_K_Pst'
p318
aS'taumdiff2_K_Pst'
p319
aa(lp320
S'tauhmean_K_Pst'
p321
aS'tauhdiff1_K_Pst'
p322
aS'tauhdiff2_K_Pst'
p323
aaS'sloh_K_Pst'
p324
aaa(lp325
(lp326
S'offc_SK_E2'
p327
aS'sloc_SK_E2'
p328
aaa(lp329
(lp330
g328
aaa(lp331
(lp332
(lp333
S'offma_Ih'
p334
aS'offmb_Ih'
p335
aa(lp336
S'sloma_Ih'
p337
aS'slomb_Ih'
p338
aaaa(lp339
(lp340
(lp341
g334
ag335
aa(lp342
g337
ag338
aaag340
aa(lp343
(lp344
(lp345
g334
ag335
aa(lp346
S'tauma_Ih'
p347
aS'taumb_Ih'
p348
aaaa(lp349
(lp350
S'offm_K_Pst'
p351
aS'offh_K_Pst'
p352
aS'slom_K_Pst'
p353
ag324
a(lp354
g317
ag318
ag319
aa(lp355
g321
ag322
ag323
aaaa(lp356
(lp357
g351
ag352
ag353
ag324
a(lp358
g317
ag318
ag319
aa(lp359
g321
ag322
ag323
aaaa(lp360
(lp361
g351
ag352
ag353
ag324
a(lp362
g317
ag318
ag319
aa(lp363
g321
ag322
ag323
aaaa(lp364
(lp365
g351
ag352
ag353
ag324
a(lp366
g317
ag318
ag319
aa(lp367
g321
ag322
ag323
aaaa(lp368
(lp369
g351
ag352
ag353
ag324
a(lp370
g317
ag318
ag319
aa(lp371
g321
ag322
ag323
aaaa(lp372
(lp373
g351
ag352
ag353
ag324
a(lp374
g317
ag318
ag319
aa(lp375
g321
ag322
ag323
aaaa(lp376
(lp377
(lp378
g144
ag145
aa(lp379
g147
ag148
aa(lp380
g191
ag192
aa(lp381
g184
ag185
aaaa(lp382
(lp383
(lp384
g144
ag145
aa(lp385
g147
ag148
aa(lp386
g191
ag192
aa(lp387
g184
ag185
aaaa(lp388
(lp389
(lp390
g144
ag145
aa(lp391
g147
ag148
aa(lp392
g191
ag192
aa(lp393
g184
ag185
aaaaa(lp394
(lp395
(lp396
F-25.9
aF-27.0
aaa(lp397
(lp398
F-37.3
aF-30.0
aaa(lp399
(lp400
F-31.4
aF0.85
aF-28.5
aF0.72
aa(lp401
F7.0
aF0.85
aF-28.5
aF0.72
aa(lp402
F-31.4
aF1.45
aF-28.5
aF0.72
aa(lp403
F7.0
aF1.45
aF-28.5
aF0.72
aa(lp404
F-31.4
aF0.85
aF16.3
aF0.72
aa(lp405
F7.0
aF0.85
aF16.3
aF0.72
aa(lp406
F-31.4
aF1.45
aF16.3
aF0.72
aa(lp407
F7.0
aF1.45
aF16.3
aF0.72
aa(lp408
F-31.4
aF0.85
aF-28.5
aF1.38
aa(lp409
F7.0
aF0.85
aF-28.5
aF1.38
aa(lp410
F-31.4
aF1.45
aF-28.5
aF1.38
aa(lp411
F7.0
aF1.45
aF-28.5
aF1.38
aa(lp412
F-31.4
aF0.85
aF16.3
aF1.38
aa(lp413
F7.0
aF0.85
aF16.3
aF1.38
aa(lp414
F-31.4
aF1.45
aF16.3
aF1.38
aa(lp415
F7.0
aF1.45
aF16.3
aF1.38
aaa(lp416
(lp417
F-38.5
aF0.46
aa(lp418
F12.9
aF0.46
aa(lp419
F-38.5
aF1.56
aa(lp420
F12.9
aF1.56
aaa(lp421
(lp422
F-27.8
aF0.89
aF-19.1
aa(lp423
F8.7
aF0.89
aF-19.1
aa(lp424
F-27.8
aF1.14
aF-19.1
aa(lp425
F8.7
aF1.14
aF-19.1
aa(lp426
F-27.8
aF0.89
aF4.7
aa(lp427
F8.7
aF0.89
aF4.7
aa(lp428
F-27.8
aF1.14
aF4.7
aa(lp429
F8.7
aF1.14
aF4.7
aaa(lp430
(lp431
F-11.2
aF-3.1
aF1.24
aa(lp432
F1.0
aF-3.1
aF1.24
aaa(lp433
(lp434
F-5.2
aF0.69
aaa(lp435
(lp436
F1.7
aaa(lp437
(lp438
F-4.9
aF-5.1
aF0.6
aF0.6
aa(lp439
F4.9
aF-5.1
aF0.6
aF0.6
aa(lp440
F-4.9
aF5.1
aF0.6
aF0.6
aa(lp441
F4.9
aF5.1
aF0.6
aF0.6
aa(lp442
F-4.9
aF-5.1
aF1.68
aF0.6
aa(lp443
F4.9
aF-5.1
aF1.68
aF0.6
aa(lp444
F-4.9
aF5.1
aF1.68
aF0.6
aa(lp445
F4.9
aF5.1
aF1.68
aF0.6
aa(lp446
F-4.9
aF-5.1
aF0.6
aF1.66
aa(lp447
F4.9
aF-5.1
aF0.6
aF1.66
aa(lp448
F-4.9
aF5.1
aF0.6
aF1.66
aa(lp449
F4.9
aF5.1
aF0.6
aF1.66
aa(lp450
F-4.9
aF-5.1
aF1.68
aF1.66
aa(lp451
F4.9
aF-5.1
aF1.68
aF1.66
aa(lp452
F-4.9
aF5.1
aF1.68
aF1.66
aa(lp453
F4.9
aF5.1
aF1.68
aF1.66
aaa(lp454
(lp455
F1.26
aaa(lp456
(lp457
F-10.9
aF0.73
aF-3.0
aF0.81
aF1.25
aa(lp458
F-10.9
aF0.73
aF3.5
aF0.81
aF1.25
aaa(lp459
(lp460
F-10.6
aF0.8
aF-5.3
aF0.66
aF0.72
aa(lp461
F3.4
aF0.8
aF-5.3
aF0.66
aF0.72
aa(lp462
F-10.6
aF1.12
aF-5.3
aF0.66
aF0.72
aa(lp463
F3.4
aF1.12
aF-5.3
aF0.66
aF0.72
aa(lp464
F-10.6
aF0.8
aF1.2
aF0.66
aF0.72
aa(lp465
F3.4
aF0.8
aF1.2
aF0.66
aF0.72
aa(lp466
F-10.6
aF1.12
aF1.2
aF0.66
aF0.72
aa(lp467
F3.4
aF1.12
aF1.2
aF0.66
aF0.72
aaa(lp468
(lp469
F6.6
aF0.75
aF0.5
aa(lp470
F6.6
aF1.19
aF0.5
aa(lp471
F6.6
aF0.75
aF1.12
aa(lp472
F6.6
aF1.19
aF1.12
aaa(lp473
(lp474
F-9.8
aF0.8
aF-15.4
aF1.05
aaa(lp475
(lp476
F-24.2
aF0.7
aF-14.5
aF0.72
aF3.52
aa(lp477
F6.1
aF0.7
aF-14.5
aF0.72
aF3.52
aa(lp478
F-24.2
aF1.24
aF-14.5
aF0.72
aF3.52
aa(lp479
F6.1
aF1.24
aF-14.5
aF0.72
aF3.52
aa(lp480
F-24.2
aF0.7
aF-14.5
aF1.28
aF3.52
aa(lp481
F6.1
aF0.7
aF-14.5
aF1.28
aF3.52
aa(lp482
F-24.2
aF1.24
aF-14.5
aF1.28
aF3.52
aa(lp483
F6.1
aF1.24
aF-14.5
aF1.28
aF3.52
aaa(lp484
(lp485
F-17.8
aF0.81
aF0.77
aa(lp486
F-17.8
aF0.81
aF1.31
aaa(lp487
(lp488
F1.3
aF1.6
aF0.87
aF0.8
aa(lp489
F1.3
aF1.6
aF1.45
aF0.8
aaa(lp490
(lp491
F-4.3
aF1.14
aF-4.4
aF0.89
aF0.53
aF0.46
aa(lp492
F-4.3
aF1.14
aF-4.4
aF1.04
aF0.53
aF0.46
aaa(lp493
(lp494
F0.67
aaa(lp495
(lp496
F-30.02
aF0.62
aF0.49
aaa(lp497
(lp498
F-4.4
aF0.95
aF20.6
aF0.97
aaa(lp499
(lp500
F0.6
aaa(lp501
(lp502
F1.97
aaa(lp503
(lp504
F1.5
aF1.4
aaa(lp505
(lp506
F4.45
aaa(lp507
(lp508
F1.1
aaa(lp509
(lp510
F0.4
aaa(lp511
(lp512
F-0.3
aI5
aF1.15
aF1.23
aaa(lp513
(lp514
F2.8
aF9.6
aF0.984
aF1.042
aaa(lp515
(lp516
F-4.0
aF-5.8
aF0.92
aF1.13
aF1.47
aaa(lp517
(lp518
F-8.1
aF2.2
aF0.97
aF0.97
aF1.59
aaa(lp519
(lp520
F6.0
aF1.16
aF1.29
aaa(lp521
(lp522
F10.0
aF-0.6
aF1.15
aF1.14
aaa(lp523
(lp524
F6.8
aaa(lp525
(lp526
F3.5
aF0.55
aF-7.1
aF17.0
aF0.69
aaa(lp527
(lp528
F-9.1
aF3.1
aaa(lp529
(lp530
F-7.6
aF4.3
aaa(lp531
(lp532
F2.0
aF2.5
aF0.5
aaa(lp533
(lp534
F0.86
aF1.24
aaa(lp535
(lp536
F0.84
aaa(lp537
(lp538
F-26.5
aF0.64
aaa(lp539
(lp540
F-25.9
aF0.6
aa(lp541
F17.7
aF0.6
aaa(lp542
(lp543
F3.9
aF0.88
aaa(lp544
(lp545
I5
aI3
aF1.11
aF0.86
aF0.5
aF0.53
aaa(lp546
(lp547
I1
aI-6
aF1.22
aF1.0
aF0.89
aF1.13
aaa(lp548
(lp549
I6
aI-8
aF1.33
aF1.0
aF0.5
aF0.87
aaa(lp550
(lp551
I-28
aI-27
aF1.11
aF0.71
aF1.13
aF2.27
aaa(lp552
(lp553
I14
aI-21
aF2.0
aF1.0
aF0.39
aF1.2
aaa(lp554
(lp555
I-13
aI-13
aF1.33
aF0.71
aF0.95
aF5.13
aaa(lp556
(lp557
F3.0
aF3.48
aF1.01
aF0.89
aaa(lp558
(lp559
F-1.11
aF5.14
aF0.6
aF1.48
aaa(lp560
(lp561
F-1.88
aF2.69
aF0.6
aF1.35
aaaa(lp562
(lp563
(lp564
(lp565
g143
a(lp566
F-25.9
aaa(lp567
g146
a(lp568
F-27.0
aaaa(lp569
(lp570
g151
a(lp571
F-37.3
aaa(lp572
g152
a(lp573
F-30.0
aaaa(lp574
(lp575
g155
a(lp576
F-31.4
aF7.0
aaa(lp577
g156
a(lp578
F0.85
aF1.45
aaa(lp579
g159
a(lp580
F-28.5
aF16.3
aaa(lp581
g160
a(lp582
F0.72
aF1.38
aaaa(lp583
(lp584
g165
a(lp585
F-38.5
aF12.9
aaa(lp586
g166
a(lp587
F0.46
aF1.56
aaaa(lp588
(lp589
g169
a(lp590
F-27.8
aF8.7
aaa(lp591
g170
a(lp592
F0.89
aF1.14
aaa(lp593
g171
a(lp594
F-19.1
aF4.7
aaaa(lp595
(lp596
g174
a(lp597
F-11.2
aF1.0
aaa(lp598
g175
a(lp599
F-3.1
aaa(lp600
g176
a(lp601
F1.24
aaaaa(lp602
(lp603
(lp604
g179
a(lp605
F-5.2
aaa(lp606
g180
a(lp607
F0.69
aaaa(lp608
(lp609
g183
a(lp610
F1.7
aaaa(lp611
(lp612
g188
a(lp613
F-4.9
aF4.9
aaa(lp614
g189
a(lp615
F-5.1
aF5.1
aaa(lp616
g190
a(lp617
F0.6
aF1.68
aaa(lp618
g193
a(lp619
F0.6
aF1.66
aaaa(lp620
(lp621
g196
a(lp622
F1.26
aaaaa(lp623
(lp624
(lp625
g199
a(lp626
F-10.9
aaa(lp627
g200
a(lp628
F0.73
aaa(lp629
g201
a(lp630
F-3.0
aF3.5
aaa(lp631
g202
a(lp632
F0.81
aaa(lp633
g203
a(lp634
F1.25
aaaa(lp635
(lp636
g206
a(lp637
F-10.6
aF3.4
aaa(lp638
g207
a(lp639
F0.8
aF1.12
aaa(lp640
g208
a(lp641
F-5.3
aF1.2
aaa(lp642
g209
a(lp643
F0.66
aaa(lp644
g210
a(lp645
F0.72
aaaa(lp646
(lp647
g213
a(lp648
F6.6
aaa(lp649
g214
a(lp650
F0.75
aF1.19
aaa(lp651
g215
a(lp652
F0.5
aF1.12
aaaa(lp653
(lp654
g218
a(lp655
F-9.8
aaa(lp656
g219
a(lp657
F0.8
aaa(lp658
g220
a(lp659
F-15.4
aaa(lp660
g221
a(lp661
F1.05
aaaa(lp662
(lp663
g224
a(lp664
F-24.2
aF6.1
aaa(lp665
g225
a(lp666
F0.7
aF1.24
aaa(lp667
g226
a(lp668
F-14.5
aaa(lp669
g227
a(lp670
F0.72
aF1.28
aaa(lp671
g228
a(lp672
F3.52
aaaa(lp673
(lp674
g231
a(lp675
F-17.8
aaa(lp676
g232
a(lp677
F0.81
aaa(lp678
g233
a(lp679
F0.77
aF1.31
aaaaa(lp680
(lp681
(lp682
g236
a(lp683
F1.3
aaa(lp684
g237
a(lp685
F1.6
aaa(lp686
g238
a(lp687
F0.87
aF1.45
aaa(lp688
g241
a(lp689
F0.8
aaaa(lp690
(lp691
g236
a(lp692
F-4.3
aaa(lp693
g246
a(lp694
F1.14
aaa(lp695
g237
a(lp696
F-4.4
aaa(lp697
g247
a(lp698
F0.89
aF1.04
aaa(lp699
g248
a(lp700
F0.53
aaa(lp701
g249
a(lp702
F0.46
aaaaa(lp703
(lp704
(lp705
g252
a(lp706
F0.67
aaaa(lp707
(lp708
g255
a(lp709
F-30.02
aaa(lp710
g256
a(lp711
F0.62
aaa(lp712
g257
a(lp713
F0.49
aaaa(lp714
(lp715
g260
a(lp716
F-4.4
aaa(lp717
g261
a(lp718
F0.95
aaa(lp719
g262
a(lp720
F20.6
aaa(lp721
g263
a(lp722
F0.97
aaaaa(lp723
(lp724
(lp725
g266
a(lp726
F0.6
aaaaa(lp727
(lp728
(lp729
g269
a(lp730
F1.97
aaaa(lp731
(lp732
g269
a(lp733
F1.5
aaa(lp734
g272
a(lp735
F1.4
aaaa(lp736
(lp737
g269
a(lp738
F4.45
aaaa(lp739
(lp740
g272
a(lp741
F1.1
aaaaa(lp742
(lp743
(lp744
g266
a(lp745
F0.4
aaaaa(lp746
(lp747
(lp748
g281
a(lp749
F-0.3
aaa(lp750
g282
a(lp751
I5
aaa(lp752
g283
a(lp753
F1.15
aaa(lp754
g284
a(lp755
F1.23
aaaa(lp756
(lp757
g281
a(lp758
F2.8
aaa(lp759
g282
a(lp760
F9.6
aaa(lp761
g283
a(lp762
F0.984
aaa(lp763
g284
a(lp764
F1.042
aaaa(lp765
(lp766
g281
a(lp767
F-4.0
aaa(lp768
g282
a(lp769
F-5.8
aaa(lp770
g283
a(lp771
F0.92
aaa(lp772
g284
a(lp773
F1.13
aaa(lp774
g289
a(lp775
F1.47
aaaa(lp776
(lp777
g281
a(lp778
F-8.1
aaa(lp779
g282
a(lp780
F2.2
aaa(lp781
g283
a(lp782
F0.97
aaa(lp783
g284
a(lp784
F0.97
aaa(lp785
g294
a(lp786
F1.59
aaaa(lp787
(lp788
g281
a(lp789
F6.0
aaa(lp790
g283
a(lp791
F1.16
aaa(lp792
g297
a(lp793
F1.29
aaaa(lp794
(lp795
g281
a(lp796
F10.0
aaa(lp797
g282
a(lp798
F-0.6
aaa(lp799
g283
a(lp800
F1.15
aaa(lp801
g284
a(lp802
F1.14
aaaaa(lp803
(lp804
(lp805
g302
a(lp806
F6.8
aaaa(lp807
(lp808
g308
a(lp809
F3.5
aaa(lp810
g309
a(lp811
F0.55
aaa(lp812
g281
a(lp813
F-7.1
aaa(lp814
g282
a(lp815
F17.0
aaa(lp816
g284
a(lp817
F0.69
aaaa(lp818
(lp819
g281
a(lp820
F-9.1
aaa(lp821
g282
a(lp822
F3.1
aaaa(lp823
(lp824
g281
a(lp825
F-7.6
aaa(lp826
g282
a(lp827
F4.3
aaaaa(lp828
(lp829
(lp830
g316
a(lp831
F2.0
aaa(lp832
g320
a(lp833
F2.5
aaa(lp834
g324
a(lp835
F0.5
aaaaa(lp836
(lp837
(lp838
g327
a(lp839
F0.86
aaa(lp840
g328
a(lp841
F1.24
aaaa(lp842
(lp843
g328
a(lp844
F0.84
aaaaa(lp845
(lp846
(lp847
g333
a(lp848
F-26.5
aaa(lp849
g336
a(lp850
F0.64
aaaa(lp851
(lp852
g341
a(lp853
F-25.9
aF17.7
aaa(lp854
g342
a(lp855
F0.6
aaaa(lp856
(lp857
g345
a(lp858
F3.9
aaa(lp859
g346
a(lp860
F0.88
aaaaa(lp861
(lp862
(lp863
g351
a(lp864
I5
aaa(lp865
g352
a(lp866
I3
aaa(lp867
g353
a(lp868
F1.11
aaa(lp869
g324
a(lp870
F0.86
aaa(lp871
g354
a(lp872
F0.5
aaa(lp873
g355
a(lp874
F0.53
aaaa(lp875
(lp876
g351
a(lp877
I1
aaa(lp878
g352
a(lp879
I-6
aaa(lp880
g353
a(lp881
F1.22
aaa(lp882
g324
a(lp883
F1.0
aaa(lp884
g358
a(lp885
F0.89
aaa(lp886
g359
a(lp887
F1.13
aaaa(lp888
(lp889
g351
a(lp890
I6
aaa(lp891
g352
a(lp892
I-8
aaa(lp893
g353
a(lp894
F1.33
aaa(lp895
g324
a(lp896
F1.0
aaa(lp897
g362
a(lp898
F0.5
aaa(lp899
g363
a(lp900
F0.87
aaaa(lp901
(lp902
g351
a(lp903
I-28
aaa(lp904
g352
a(lp905
I-27
aaa(lp906
g353
a(lp907
F1.11
aaa(lp908
g324
a(lp909
F0.71
aaa(lp910
g366
a(lp911
F1.13
aaa(lp912
g367
a(lp913
F2.27
aaaa(lp914
(lp915
g351
a(lp916
I14
aaa(lp917
g352
a(lp918
I-21
aaa(lp919
g353
a(lp920
F2.0
aaa(lp921
g324
a(lp922
F1.0
aaa(lp923
g370
a(lp924
F0.39
aaa(lp925
g371
a(lp926
F1.2
aaaa(lp927
(lp928
g351
a(lp929
I-13
aaa(lp930
g352
a(lp931
I-13
aaa(lp932
g353
a(lp933
F1.33
aaa(lp934
g324
a(lp935
F0.71
aaa(lp936
g374
a(lp937
F0.95
aaa(lp938
g375
a(lp939
F5.13
aaaaa(lp940
(lp941
(lp942
g378
a(lp943
F3.0
aaa(lp944
g379
a(lp945
F3.48
aaa(lp946
g380
a(lp947
F1.01
aaa(lp948
g381
a(lp949
F0.89
aaaa(lp950
(lp951
g384
a(lp952
F-1.11
aaa(lp953
g385
a(lp954
F5.14
aaa(lp955
g386
a(lp956
F0.6
aaa(lp957
g387
a(lp958
F1.48
aaaa(lp959
(lp960
g390
a(lp961
F-1.88
aaa(lp962
g391
a(lp963
F2.69
aaa(lp964
g392
a(lp965
F0.6
aaa(lp966
g393
a(lp967
F1.35
aaaaaa.

Loading data, please wait...