LFP signature of monosynaptic thalamocortical connection (Hagen et al 2017)


Help downloading and running models
Accession:238920
"A resurgence has taken place in recent years in the use of the extracellularly recorded local field potential (LFP) to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments, the cortical LFP is measured by multielectrodes covering several cortical lamina and averaged on spontaneous spikes of thalamocortical (TC) cells. Using a well established forward-modeling scheme, we investigated the biophysical origin of this stLFP signature with simultaneous synaptic activation of cortical layer-4 neurons, mimicking the effect of a single afferent spike from a single TC neuron. ..."
Reference:
1 . Hagen E, Fossum JC, Pettersen KH, Alonso JM, Swadlow HA, Einevoll GT (2017) Focal Local Field Potential Signature of the Single-Axon Monosynaptic Thalamocortical Connection. J Neurosci 37:5123-5143 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Synapse;
Brain Region(s)/Organism: Thalamus; Neocortex;
Cell Type(s): Neocortex layer 4 interneuron; Neocortex layer 4 neuron; Neocortex layer 4 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Activity Patterns; Evoked LFP;
Implementer(s):
(located via links below)
Loading data, please wait...