Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

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Accession:239744
We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.
Reference:
1 . Blackwell KT, Salinas AG, Tewatia P, English B, Kotaleski JH, Lovinger DM (2018) Molecular Mechanisms Underlying Striatal Synaptic Plasticity: Relevance to Chronic Alcohol Consumption and Seeking. Eur J Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network; Synapse;
Brain Region(s)/Organism: Basal ganglia; Striatum;
Cell Type(s): Neostriatum spiny direct pathway neuron;
Channel(s):
Gap Junctions:
Receptor(s): D1; mGluR5; M1; M4;
Gene(s):
Transmitter(s): Acetylcholine; Dopamine; Endocannabinoid; Glutamate;
Simulation Environment: NeuroRD;
Model Concept(s): G-protein coupled; Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; M1; M4; mGluR5; D1; Acetylcholine; Dopamine; Glutamate; Endocannabinoid;
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Model_SPN_STDP-protFino-isiback.xml
Model_SPN_STDP-protFino-isifor.xml
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Model_SPNspine_GapD_alcohol-stim20hz-alcNMDA_IC.xml
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Model_SPNspine_GapD_alcohol-stimtheta-alcNMDA.xml
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Model_SPNspineAChm4R_Gshydr5_GapD_plc-stimtheta-blockM4.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-BlockCyA-bathCa.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-sp1-stimtheta.xml
Model_SPNspineAChm4R_Gshydr5_GapD-sp2adj-stim20hz.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-sp2other-stim20hz.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-sp2sep-stim20hz.xml
Model_SPNspineAChm4R_Gshydr5_GapD-sp2sep-stimtheta.xml
Model_SPNspineAChm4R_Gshydr5_GapD-sp3sep-stim20hz.xml
Model_SPNspineAChm4R_Gshydr5_GapD-sp3sep-stimtheta.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-AChflat.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-AChnoB.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-AChnoDip.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-blockM4.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-blockPKA.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-blockPKA2.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-noCKp.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-noDa.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-noReb_DaDelay.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-noReb_lowDaDec2.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stim20hz-noReb_lowDaDec3.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-AChflat.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-AChnoB.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-AChnoDip.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-blockM1.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-blockM4.xml
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Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-blockPKA.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-blockPKA2.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-noCKp.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-noDa.xml
Model_SPNspineAChm4R_Gshydr5_GapD-stimtheta-noReb_DaDec1.xml
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Morph1.5um.xml
Morph20um.xml
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NeuroRDsims.bat
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Stim_CaBathCyA.xml
Stim_CaBathOA.xml
Stim_DaBathCyA.xml
Stim20hzACh-sp1.xml
Stim20hzACh-sp2adj.xml
Stim20hzACh-sp2other.xml
Stim20hzACh-sp2sep.xml
Stim20hzACh-sp3sep.xml
StimCouple20hz_alcohol_LowDaDec3-1tr.xml
StimCouple20hz_alcoholDa_LowDaDec3-1tr.xml
StimCouple20hz_CKpblock-10sITI.xml
StimCouple20hz_DaDelay-10sITI.xml
StimCouple20hz_m1block-10sITI.xml
StimCouple20hz_m4block-10sITI.xml
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StimCouple20hzAChNoDa-10sITI.xml
StimCouple20hzAChNoDip-10sITI.xml
StimCouple20hzAChNoGlu-10sITI.xml
StimCouple20hzAChNoRebound_LowDaDec2-10sITI.xml
StimCouple20hzAChNoRebound_LowDaDec3-10sITI.xml
StimCouple20hzAChNoRebound_LowDaDec3-10sITI_onset50.xml
StimCouple20hzAChNoRebound_LowDaDec3-1tr.xml
StimCouple20hz-flatACh-10sITI.xml
StimCouple20hz-noAChburst-10sITI.xml
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StimCoupleDa0.3.xml
StimCoupleDa1.xml
StimCoupleDa10.xml
StimCoupleSTDP_Fino_backward.xml
StimCoupleSTDP_Fino_forward.xml
StimCoupleSTDP_PK_backward.xml
StimCoupleSTDP_PK_forward.xml
StimCoupleTheta10hz_alcohol_DaDec1-1tr.xml
StimCoupleTheta10hz_alcoholDa_DaDec1-1tr.xml
StimCoupleTheta10hz_CKpblock-15sITI.xml
StimCoupleTheta10hz_DaDelay-15sITI.xml
StimCoupleTheta10hz_m1block-15sITI.xml
StimCoupleTheta10hz_m4block-15sITI.xml
StimCoupleTheta10hzACh-15sITI.xml
StimCoupleTheta10hzAChNoDa-15sITI.xml
StimCoupleTheta10hzAChNoDip-15sITI.xml
StimCoupleTheta10hzAChNoGlu-15sITI.xml
StimCoupleTheta10hzAChNoRebound_DaDec1-15sITI.xml
StimCoupleTheta10hzAChNoRebound_DaDec1-15sITI_onset50.xml
StimCoupleTheta10hzAChNoRebound_DaDec1-1tr.xml
StimCoupleTheta10hz-flatACh-15sITI.xml
StimCoupleTheta10hz-noAChburst-15sITI.xml
StimDend_CaBath.xml
StimDend_DaBath.xml
StimDend_DaCaBath.xml
StimTheta10hzACh-sp1.xml
StimTheta10hzACh-sp2adj.xml
StimTheta10hzACh-sp2other.xml
StimTheta10hzACh-sp2sep.xml
StimTheta10hzACh-sp3sep.xml
                            
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