Effect of cortical D1 receptor sensitivity on working memory maintenance (Reneaux & Gupta 2018)

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Accession:240382
Alterations in cortical D1 receptor density and reactivity of dopamine-binding sites, collectively termed as D1 receptor-sensitivity in the present study, have been experimentally shown to affect the working memory maintenance during delay-period. However, computational models addressing the effect of D1 receptor-sensitivity are lacking. A quantitative neural mass model of the prefronto-mesoprefrontal system has been proposed to take into account the effect of variation in cortical D1 receptor-sensitivity on working memory maintenance during delay. The model computes the delay-associated equilibrium states/operational points of the system for different values of D1 receptor-sensitivity through the nullcline and bifurcation analysis. Further, to access the robustness of the working memory maintenance during delay in the presence of alteration in D1 receptor-sensitivity, numerical simulations of the stochastic formulation of the model are performed to obtain the global potential landscape of the dynamics.
Reference:
1 . Reneaux M, Gupta R (2018) Prefronto-cortical dopamine D1 receptor sensitivity can critically influence working memory maintenance during delayed response tasks PLOS ONE 13(5):e0198136
Model Information (Click on a link to find other models with that property)
Model Type: Neural mass;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): D1;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: MATLAB;
Model Concept(s): Bifurcation; Stochastic simulation; Working memory; Schizophrenia;
Implementer(s): Reneaux, Melissa [reneauxm5 at gmail.com]; Gupta, Rahul [gupta.sbt at gmail.com];
Search NeuronDB for information about:  D1; Dopamine;
 
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