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Effect of cortical D1 receptor sensitivity on working memory maintenance (Reneaux & Gupta 2018)
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Alterations in cortical D1 receptor density and reactivity of dopamine-binding sites, collectively termed as D1 receptor-sensitivity in the present study, have been experimentally shown to affect the working memory maintenance during delay-period. However, computational models addressing the effect of D1 receptor-sensitivity are lacking. A quantitative neural mass model of the prefronto-mesoprefrontal system has been proposed to take into account the effect of variation in cortical D1 receptor-sensitivity on working memory maintenance during delay. The model computes the delay-associated equilibrium states/operational points of the system for different values of D1 receptor-sensitivity through the nullcline and bifurcation analysis. Further, to access the robustness of the working memory maintenance during delay in the presence of alteration in D1 receptor-sensitivity, numerical simulations of the stochastic formulation of the model are performed to obtain the global potential landscape of the dynamics.
Reneaux M, Gupta R (2018) Prefronto-cortical dopamine D1 receptor sensitivity can critically influence working memory maintenance during delayed response tasks
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Prefrontal cortex (PFC);
Reneaux, Melissa [reneauxm5 at gmail.com];
Gupta, Rahul [gupta.sbt at gmail.com];
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