MDD: the role of glutamate dysfunction on Cingulo-Frontal NN dynamics (Ramirez-Mahaluf et al 2017)


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Accession:240954
" ...Currently, no mechanistic framework describes how network dynamics, glutamate, and serotonin interact to explain MDD symptoms and treatments. Here, we built a biophysical computational model of 2 areas (vACC and dlPFC) that can switch between emotional and cognitive processing. (Major Depression Disease) MDD networks were simulated by slowing glutamate decay in vACC and demonstrated sustained vACC activation. ..."
Reference:
1 . Ramirez-Mahaluf JP, Roxin A, Mayberg HS, Compte A (2017) A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics. Cereb Cortex 27:660-679 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Connectionist Network;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s): Abstract integrate-and-fire leaky neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Serotonin; Glutamate;
Simulation Environment: Brian (web link to model);
Model Concept(s): Activity Patterns; Deep brain stimulation; Oscillations; Gamma oscillations; Major Depression Disease (MDD); Beta oscillations;
Implementer(s): Ramirez-Mahaluf, Juan P [jpramirezmahaluf at gmail.com];
Search NeuronDB for information about:  Glutamate; Serotonin;
(located via links below)
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