Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)

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Accession:241165
This archive instantiates the single-cell cortical models used in (Aberra et al. 2018) and sets up extracellular stimulation with either a point-current source, to simulate intracortical microstimulation (ICMS), or a uniform E-field distribution, with a monophasic, rectangular pulse waveform in both cases.
Reference:
1 . Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation J. Neural Eng. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex; Barrel cortex;
Cell Type(s): Myelinated neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models;
Implementer(s): Aberra, Aman [aman.aberra at duke.edu];
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AberraEtAl2018
mechanisms
Ca.mod *
Ca_HVA.mod *
Ca_LVAst.mod
CaDynamics_E2.mod *
Ih.mod *
Im.mod
K_Pst.mod
K_Tst.mod
Nap_Et2.mod
NaTa_t.mod
NaTs2_t.mod
ProbAMPANMDA_EMS.mod *
ProbGABAAB_EMS.mod *
SK_E2.mod *
SKv3_1.mod *
xtra.mod
                            
: $Id: xtra.mod,v 1.4 2014/08/18 23:15:25 ted Exp ted $
: 2018/05/20 Modified by Aman Aberra 

NEURON {
	SUFFIX xtra
	RANGE es : (es = max amplitude of the potential)		
	RANGE x, y, z, type, order
	GLOBAL stim : (stim = normalized waveform)
	POINTER ex 
}

PARAMETER {	
	es = 0 (mV)
	x = 0 (1) : spatial coords
	y = 0 (1)
	z = 0 (1)		
	type = 0 (1) : numbering system for morphological category of section - unassigned is 0
	order = 0 (1) : order of branch/collateral. 
}

ASSIGNED {
	v (millivolts)
	ex (millivolts)
	stim (unitless) 		
	area (micron2)
}

INITIAL {
	ex = stim*es	
}


BEFORE BREAKPOINT { : before each cy' = f(y,t) setup
  ex = stim*es
}


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