Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:241165
This archive instantiates the single-cell cortical models used in (Aberra et al. 2018) and sets up extracellular stimulation with either a point-current source, to simulate intracortical microstimulation (ICMS), or a uniform E-field distribution, with a monophasic, rectangular pulse waveform in both cases.
Reference:
1 . Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation. J Neural Eng 15:066023 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex; Barrel cortex;
Cell Type(s): Myelinated neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models;
Implementer(s): Aberra, Aman [aman.aberra at duke.edu];
/
AberraEtAl2018
cells
L5_TTPC2_cADpyr232_4
mechanisms
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
NaTs2_t.mod *
ProbAMPANMDA_EMS.mod *
ProbGABAAB_EMS.mod *
SK_E2.mod *
SKv3_1.mod *
                            
:Comment :
:Reference : :		Kole,Hallermann,and Stuart, J. Neurosci. 2006

NEURON	{
	SUFFIX Ih
	NONSPECIFIC_CURRENT ihcn
	RANGE gIhbar, gIh, ihcn 
}

UNITS	{
	(S) = (siemens)
	(mV) = (millivolt)
	(mA) = (milliamp)
}

PARAMETER	{
	gIhbar = 0.00001 (S/cm2) 
	ehcn =  -45.0 (mV)
}

ASSIGNED	{
	v	(mV)
	ihcn	(mA/cm2)
	gIh	(S/cm2)
	mInf
	mTau
	mAlpha
	mBeta
}

STATE	{ 
	m
}

BREAKPOINT	{
	SOLVE states METHOD cnexp
	gIh = gIhbar*m
	ihcn = gIh*(v-ehcn)
}

DERIVATIVE states	{
	rates()
	m' = (mInf-m)/mTau
}

INITIAL{
	rates()
	m = mInf
}

PROCEDURE rates(){
	UNITSOFF
        if(v == -154.9){
            v = v + 0.0001
        }
		mAlpha =  0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1)
		mBeta  =  0.001*193*exp(v/33.1)
		mInf = mAlpha/(mAlpha + mBeta)
		mTau = 1/(mAlpha + mBeta)
	UNITSON
}

Loading data, please wait...