was recently proposed that at onset of an (Action Potential) AP the soma and the (Axon Initial Segment) AIS form
We study the extracellular signature (the extracellular
action potential, EAP) generated by such a dipole.
demonstrate the formation of the dipole and its extracellular
signature in detailed morphological models of a reconstructed
Then, we study the EAP waveform and its spatial
dependence in models with axonal AP initiation and contrast it with
the EAP obtained in models with somatic AP initiation.
We show that in
the models with axonal AP initiation the dipole forms between
somatodendritic compartments and the AIS, and not between soma and
dendrites as in the classical models.
Telenczuk M, Brette R, Destexhe A, Telenczuk B (2018) Contribution of the Axon Initial Segment to Action Potentials Recorded Extracellularly. eNeuro [PubMed]