Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

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Accession:243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 . Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell Reports 24(6):1536-1549 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): Ca pump; I K; I K,Ca; I Na,p; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Synaptic Integration; Dendritic Action Potentials; Detailed Neuronal Models;
Implementer(s): Zang, Yunliang ;
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I K; I h; I K,Ca; Ca pump;
: Ih current
: Created 8/6/02 - nwg
: for the formulation of Angelo's data, the original parameter correspond to a maximum value of 250 ms. In their supplement data, this value is about 325 ms. So I corrected a value1.3
NEURON {
	SUFFIX hpkj
	NONSPECIFIC_CURRENT i
	RANGE ghbar, eh, i
	GLOBAL ninf, ntau
:    THREADSAFE	
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(S) = (siemens)
}
CONSTANT {
	q10 = 3

}
PARAMETER {
	v	 	(mV)
	celsius (degC)
	ghbar = .0001	(S/cm2)

	eh = -30	(mV)
}

ASSIGNED {
	i (mA/cm2)
	qt
	ninf
	ntau
}

STATE {
	n
}

INITIAL {
    qt = q10^((celsius-22 (degC))/10 (degC))
	rates(v)
	n = ninf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	i = ghbar*n*(v - eh)
}

DERIVATIVE states {
	rates(v)
	n' = (ninf - n)/ntau
}

PROCEDURE rates(v (mV)) {
:	ninf = 1/(1+exp((v+90.3+3)/9.9))
	ninf = 1/(1+exp((v+90.3+3+3)/9.67))

	ntau = 1000/(0.62*(exp((v+68)/-22)+exp((v+68)/7.14)))/qt/1.3
}

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