Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 . Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell Reports 24(6):1536-1549 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): Ca pump; I K; I K,Ca; I Na,p; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Synaptic Integration; Dendritic Action Potentials; Detailed Neuronal Models;
Implementer(s): Zang, Yunliang ;
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I K; I h; I K,Ca; Ca pump;
TITLE Purkinje Leak Current

: A passive purkinje cell leak current
NEURON {
	SUFFIX lkpkj
	NONSPECIFIC_CURRENT i
	RANGE i, e, g
}
PARAMETER {
	g = 5e-5	(siemens/cm2)  < 0, 1e9 >
	e = -60	(millivolt)
}
ASSIGNED {
	i  (milliamp/cm2)
	v  (millivolt)
}
BREAKPOINT { i = g*(v - e) }

Loading data, please wait...