Disentangling astroglial physiology with a realistic cell model in silico (Savtchenko et al 2018)

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Accession:243508
"Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. ..."
Reference:
1 . Savtchenko LP, Bard L, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA (2018) Disentangling astroglial physiology with a realistic cell model in silico. Nat Commun 9:3554 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Glia;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Astrocyte;
Channel(s): I Calcium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON; MATLAB; C or C++ program;
Model Concept(s): Calcium waves; Calcium dynamics; Potassium buffering; Volume transmission; Membrane Properties;
Implementer(s): Savtchenko, Leonid P [leonid.savtchenko at ucl.ac.uk];
Search NeuronDB for information about:  I Calcium; I Potassium; Kir; Glutamate;
:NMODL for Sinusoid IClamp: 
:Sinusoid current clamp 
: The code was download from https://www.neuron.yale.edu/phpBB/viewtopic.php?t=1250

NEURON {
    POINT_PROCESS IClampSin
    RANGE del, dur, amp, freq, phase, bias 
    ELECTRODE_CURRENT i
} 

UNITS {
    (nA) = (nanoamp)
}

PARAMETER {
    del=100000 (ms) 
    dur=0 (ms) 
    amp=0 (nA) 
    freq=1 (Hz) 
    phase=0 (rad) 
    bias=0 (nA) 
    PI=3.14159265358979323846
}

ASSIGNED {
    i (nA)
}

BREAKPOINT {
    at_time(del) 
    at_time(del+dur)

    if (t < del+dur && t>del) { 
        i = amp*sin(2*PI*freq*(t-del)/1000+phase)+bias 
    } else {
        i = 0
    }
}

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