Disentangling astroglial physiology with a realistic cell model in silico (Savtchenko et al 2018)

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Accession:243508
"Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. ..."
Reference:
1 . Savtchenko LP, Bard L, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA (2018) Disentangling astroglial physiology with a realistic cell model in silico. Nat Commun 9:3554 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Glia;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Astrocyte;
Channel(s): I Calcium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON; MATLAB; C or C++ program;
Model Concept(s): Calcium waves; Calcium dynamics; Potassium buffering; Volume transmission; Membrane Properties;
Implementer(s): Savtchenko, Leonid P [leonid.savtchenko at ucl.ac.uk];
Search NeuronDB for information about:  I Calcium; I Potassium; Kir; Glutamate;
Summary min-max
------------------------------
0.030782	 1.679250

Normal cylinders min-max
------------------------------
0.056102	 1.679250

Intermediate cylinders min-max
------------------------------
0.030782	 1.616313

Range	 Summ.	 Inter.	 Norm.
------------------------------
0.030782 78		 41		 37
0.195629 8		 3		 5
0.360476 8		 4		 4
0.525322 5		 2		 3
0.690169 16		 9		 7
0.855016 2		 0		 2
1.019863 10		 6		 4
1.184709 7		 3		 4
1.349556 5		 2		 3
1.514403 1		 0		 1
1.679250

NEURON
0.329693
8
0.061564 0.585714
0.391258 0.628571
0.720951 0.685714
1.050645 0.714286
1.380338 0.842857
2.039725 0.928571
2.369419 0.971429
2.699112 1.000000
10
0.061564 0.528571
0.391258 0.600000
0.720951 0.657143
1.050645 0.700000
1.380338 0.800000
1.710032 0.828571
2.039725 0.885714
2.369419 0.942857
2.699112 0.985714
3.028806 1.000000

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