"Subthreshold fluctuations in neuronal membrane potential traces
contain nonlinear components, and employing nonlinear models might
improve the statistical inference. We propose a new strategy to
estimate synaptic conductances, which has been tested using in silico
data and applied to in vivo recordings. The model is constructed to
capture the nonlinearities caused by subthreshold activated currents,
and the estimation procedure can discern between excitatory and
inhibitory conductances using only one membrane potential trace.
... The results show an improvement
compared to existent procedures for the models tested here."
Vich C, Berg RW, Guillamon A, Ditlevsen S (2017) Estimation of Synaptic Conductances in Presence of Nonlinear Effects Caused by Subthreshold Ionic Currents. Front Comput Neurosci 11:69 [PubMed]