Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
//SimParams.g

//*************** Parameters to control model (p file, spinesYesNo) and simulations
str 	neuronname = "/cell"
str     pfile="MScell/MScelltaperspines.p"     //"MScell/MScellTest.p"       //
float   outputclock=1e-4  //output time step (Sec)
float   simdt=5e-6        // Simulation time step (Second) 
int     spinesYesNo=1
int     synYesNo=1
str 	DA="UI"
str     whichSpines = "1,2,3"
float   initSim = 0.9
int TooFast = 30 //what is the frequency that results in depletion of synaptic vesicles

//Parameters for learning rule

int     plastYesNo = 0
float   post_thresh_hi = .46e-3 //0.5 
float   post_thresh_lo = 0.2e-3  //0.2
float   dur_hi = 2.e-3 //
float   dur_lo = .032  //0.2

//whether to elicit and single pulses before and after plasticity protocol
int pulseYN=0
int desensYesNo=0
str facchan="/cell/desens"

int GABAYesNo = 0
// phasic GABA switch
int GABAtonic =  0//tonic GABA switch
str GABAstim = "tertdend1_1"

//Parameters for current injection for IV/IF curves
str input_name = "spine_stim"
str GABA_input = "GABA_stim"
float SMALLNUMBER=1e-15
str precell="/othercell"

//Parameters for current injection for IV/IF curves
str injectName="/injectCurr"
float injectstart=-300e-12 //1e-9
float inc=100e-12          //20e-12
float delay=0.1
float duration=0.25       //0.005
int numcurr=7
float basal_current=0
float basal_current_inj = 0
//parameters for current injection to produce AP during upstate or STDP
float upstate_time = 0.3
float AP_durtime = 0.005 //duration of AP depolarization at soma, 5 ms

//parameters for synaptic stimulation
int tertdendstart=1
int tertdendsegstart=1
str stimcomp
str multispinefile
str multispinehead

//output files.  Xfile is name of ascii object and suffix for filename
//Xhead is the header written to the file
//Vm output is required, Gk and Ca are optional
str Vmfile="Vm"
str Vmhead
int CaOut=1
str Cafile
str Cahead
int GkOut=1
str Gkfile
str Gkhead
str Ikfile
str Ikhead
str multispinefile
str multispinehead
str spinefile
str spinehead
str presynfile
int somainjout = 0
str somainjfile = "somaInj"

//list of compartments, channels and calcium objects for output, comma separated
str comps="soma,primdend1,secdend11,tertdend1_1,tertdend1_2,tertdend1_3,tertdend1_4,tertdend1_5,tertdend1_6,tertdend1_7" //These should include comps of stim spines to see NMDA
str chans="CaL13_channel,CaL12_channel,CaR_channel,CaT32_channel,CaT33_channel" //"X" if no channels.  
//these must match the calcium type, i.e. pools for type 1 and CaMN, etc for type 0

str CaBufs="CaMN,CaMC,calbindin,FixedBuffer"//"Ca_pool_LT,Ca_pool_NR,Ca_pool_all,Ca_pool_nmda" // X = just calcium, no buffers


    //***********input rates for Glutamate, and durations when doing a gradient.
    //most of these values should be passed in as parameters or declared in SimParams
    //make the secondRate and thirdRate = first rate when second_time and third_time = 0
//*rates used for gradient and flat inputs, multiply by 10
//18: high=*50, med=*3, low=*1, gaba=*7
//19: high=*40, med=*5, low=*2, gaba=*7
//flat: rate=*4 gaba=*7
float first_time = 0.01
float second_time  = 0.2

int Rate1
int Rate2
int Rate3
int GabaRate=70

create table APtime
int  xmax=7
call  APtime  TABCREATE 7 0 7
setfield APtime table->table[0] 0.005 \
                table->table[1] 0.010 \
                table->table[2] 0.020 \
                table->table[3] 0.030 \
                table->table[4] 0.050 \
                table->table[5] 0.100 \
                table->table[6] 0.175 \
                table->table[7] 0.290 

//From STDP files:
//1: high=*50, med =*1, low =/1.5, gaba = *2
//2: high=*40, med =*1, low =/1.5, gaba = *2
//3: high=*40, med =*1, low =/1.5, gaba = *3
//*****4: high=*40, med =*1, low =/1.5, gaba = *4
//5: high=*60, med =/2, low =/5, gaba = *4
//6: high=*30, med =*1, low =/1.5, gaba = *4

/* Three variations for stimulation in PlasStim
a. PreStim=0 indicates stimulate a single compartment,
    second parameter must be name of compartment
b. PreStim between 0 and 1.0 indicates stimulate a percentage
    of glutamate synapses.  The PreStim value is treated as percent.
    in this case, StimComp should be either
    b1. "any", meaning stimulate a percentage of _any_ compartments, or
    b2. a value indicating minimum distance from soma for stimulation.
        of course, setting a value = 0 is the same as "any"
Same variations plus one more for stimulation in STDP
If PreStim <= 0, no stim, only AP*/


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