Stimulated and physiologically induced APs: frequency and fiber diameter (Sadashivaiah et al 2018)

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"... In this study, we aim to quantify the effects of stimulation frequency and fiber diameter on AP (Action Potential) interactions involving collisions and loss of excitability. We constructed a mechanistic model of a myelinated nerve fiber receiving two inputs: the underlying physiological activity at the terminal end of the fiber, and an external stimulus applied to the middle of the fiber. We define conduction reliability as the percentage of physiological APs that make it to the somatic end of the nerve fiber. At low input frequencies, conduction reliability is greater than 95% and decreases with increasing frequency due to an increase in AP interactions. Conduction reliability is less sensitive to fiber diameter and only decreases slightly with increasing fiber diameter. Finally, both the number and type of AP interactions significantly vary with both input frequencies and fiber diameter. ..."
1 . Sadashivaiah V, Sacré P, Guan Y, Anderson WS, Sarma SV (2018) Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter Journal of Computational Neuroscience
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron;
Gap Junctions:
Simulation Environment: MATLAB (web link to model); NEURON (web link to model);
Model Concept(s): Action Potentials; Axonal Action Potentials; Action Potential Initiation; Reliability;
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