Bursting in dopamine neurons (Li YX et al 1996)


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Accession:247656
"Burst firing of dopaminergic neurons of the substantia nigra pars compacta can be induced in vitro by the glutamate agonist N-methyl-D-aspartate. It has been suggested that the interburst hyperpolarization is due to Na+ extrusion by a ouabain-sensitive pump (Johnson et al. (1992) Science 258, 665-667). We formulate and explore a theoretical model, with a minimal number of currents, for this novel mechanism of burst generation. This minimal model is further developed into a more elaborate model based on observations of additional currents and hypotheses about their spatial distribution in dopaminergic neurons ... Responses of the model to a number of electrophysiological and pharmacological stimuli are consistent with known responses observed under similar conditions. ..."
Reference:
1 . Li YX, Bertram R, Rinzel J (1996) Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons. Neuroscience 71:397-410 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Sodium;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Dopamine; Glutamate;
Simulation Environment: CellML (web link to model);
Model Concept(s): Bursting; Action Potentials; Sodium pump; Activity Patterns; Oscillations;
Implementer(s):
Search NeuronDB for information about:  NMDA; I Sodium; Dopamine; Glutamate;
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