Action potential-evoked Na+ influx similar in axon and soma (Fleidervish et al. 2010) (Python)

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Accession:249404
"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential-associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
Reference:
1 . Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma. Nat Neurosci 13:852-60 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I Sodium; I Na,p; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Action Potentials; Active Dendrites; Reaction-diffusion;
Implementer(s): McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB for information about:  Neocortex U1 L5B pyramidal pyramidal tract GLU cell; I Na,p; I Sodium; I Potassium;
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