Dynamics of sleep oscillations coupled to brain temperature on multiple scales (Csernai et al 2019)


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Accession:258478
"Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales."
Reference:
1 . Csernai M, Borbély S, Kocsis K, Burka D, Fekete Z, Balogh V, Káli S, Emri Z, Barthó P (2019) Dynamics of sleep oscillations is coupled to brain temperature on multiple scales. J Physiol [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus reticular nucleus GABA cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Channel(s):
Gap Junctions:
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Simulation Environment: NEURON (web link to model); MATLAB (web link to model);
Model Concept(s): Temperature; Brain Rhythms; Sleep; Activity Patterns; Oscillations;
Implementer(s): Burka, Dávid ; Emri, Zsuzsa ; Káli, Szabolcs ;
Search NeuronDB for information about:  Thalamus reticular nucleus GABA cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
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