Gamma oscillations in hippocampal interneuron networks (Wang, Buzsaki 1996)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:26997
The authors investigated the hypothesis that 20-80Hz neuronal (gamma) oscillations can emerge in sparsely connected network models of GABAergic fast-spiking interneurons. They explore model NN synchronization and compare their results to anatomical and electrophysiological data from hippocampal fast spiking interneurons.
Reference:
1 . Wang XJ, Buzsáki G (1996) Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model. J Neurosci 16:6402-13 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Abstract Wang-Buzsaki neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]; Lytton, William [bill.lytton at downstate.edu];
Search NeuronDB for information about:  GabaA; I Na,t; I K;
load_file("nrngui.hoc")
objectvar save_window_, rvp_
objectvar scene_vector_[4]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin SingleCompartment
{
load_file("single.hoc")
}
ocbox_ = new SingleCompartment(0)
ocbox_.inserter = new Inserter(0)
{object_push(ocbox_.inserter)}
{
mt.select("pas") i = mt.selected()
ms[i] = new MechanismStandard("pas")
ms[i].set("g_pas", 0.0001, 0)
ms[i].set("e_pas", -65, 0)
mstate[i]= 1
maction(i)
mt.select("kdr") i = mt.selected()
ms[i] = new MechanismStandard("kdr")
ms[i].set("gmax_kdr", 0.009, 0)
mstate[i]= 1
maction(i)
mt.select("naf") i = mt.selected()
ms[i] = new MechanismStandard("naf")
ms[i].set("gmax_naf", 0.035, 0)
mstate[i]= 1
maction(i)
}
{object_pop() doNotify()}
{object_push(ocbox_)}
{inserter.v1.map()}
{endbox()}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.vbox
ocbox_.map("SingleCompartment", 311, 109, 91.2, 133.44)
}
objref ocbox_
//End SingleCompartment


//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
soma ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("IClamp") i = mt.selected()
ms[i] = new MechanismStandard("IClamp")
ms[i].set("del", 0, 0)
ms[i].set("dur", 1e+09, 0)
ms[i].set("amp", 0.001, 0)
mt.select("IClamp") i = mt.selected() maction(i)
hoc_ac_ = 0.5
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 337, 298, 208.32, 326.4)
}
objref ocbox_
//End PointProcessManager

{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 50
xvalue("t","t", 2 )
tstop = 50
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.268024
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(7,105)
}
{
save_window_ = new Graph(0)
save_window_.size(0,50,-80,40)
scene_vector_[3] = save_window_
{save_window_.view(0, -80, 50, 120, 426, 28, 300.48, 200.32)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{
xpanel("Temperature", 0)
celsius = 37
xvalue("celsius","celsius", 1,"", 0, 1 )
xpanel(337,668)
}
{
xpanel("soma(0 - 1) (Parameters)", 0)
xlabel("soma(0 - 1) (Parameters)")
xlabel("nseg = 1")
soma.L = 3.1831
xvalue("L","soma.L", 1,"define_shape()", 0, 0 )
soma.diam = 10
xvalue("diam","soma.diam", 1,"", 0, 0 )
soma.cm = 1
xvalue("cm","soma.cm", 1,"", 0, 0 )
soma.g_pas = 0.0001
xvalue("g_pas","soma.g_pas", 1,"", 0, 0 )
soma.e_pas = -65
xvalue("e_pas","soma.e_pas", 1,"", 0, 0 )
soma.gmax_kdr = 0.009
xvalue("gmax_kdr","soma.gmax_kdr", 1,"", 0, 0 )
soma.gmax_naf = 0.035
xvalue("gmax_naf","soma.gmax_naf", 1,"", 0, 0 )
xpanel(573,301)
}

//Begin VariableTimeStep
{
ocbox_ = NumericalMethodPanel[0]
ocbox_ = ocbox_.b1
ocbox_.map("VariableTimeStep", 9, 499, 272.64, 106.56)
}
objref ocbox_
//End VariableTimeStep

objectvar scene_vector_[1]
{doNotify()}

Loading data, please wait...