Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)

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Accession:279
In Destexhe, Neubig, Ulrich, and Huguenard (1998) experiments and models examine low threshold calcium current's (IT, or T-current) distribution in thalamocortical (TC) cells. Multicompartmental modeling supports the hypothesis that IT currents have a density at least several fold higher in the dendrites than the soma. The IT current contributes significantly to rebound bursts and is thought to have important network behavior consequences. See the paper for details. See also http://cns.iaf.cnrs-gif.fr Correspondance may be addressed to Alain Destexhe: Destexhe@iaf.cnrs-gif.fr
Reference:
1 . Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18:3574-88 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I Na,t; I T low threshold; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Parameter Fitting; Simplified Models; Influence of Dendritic Geometry; Detailed Neuronal Models; Calcium dynamics; Rebound firing;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I Na,t; I T low threshold; I K;
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dendtc
cells
README
cadecay.mod *
hh2.mod *
ITGHK.mod *
VClamp.mod *
El.oc *
loc200.oc
loc3.oc *
locD.oc
mosinit.hoc *
rundemo.hoc
tc1_cc.oc
tc200_cc.oc
tc200_vc.oc
tc3_cc.oc
tcD_vc.oc
                            
//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

load_file("nrngui.hoc")

strdef tstr

objref El

electrodes_present=0	// after electrodes are created they must be
			// destroyed if simulation restarted

proc destroy_elec() {
	execute("objref stim, vc",El)
}

	xpanel("Simulations of TC cells")
	xlabel("Simulations of TC cells with IT.  Destexhe et al 1996")
	xbutton("Burst behavior in single-compartment model","restart(\"tc1_cc\")")
	xbutton("Burst behavior in 3-compartment model","restart(\"tc3_cc\")")
        xbutton("Burst behavior in detailed cell model","restart(\"tc200_cc\")")
        xbutton("Voltage-clamp in detailed cell model","restart(\"tc200_vc\")")
        xbutton("Voltage-clamp in dissociated cell model","restart(\"tcD_vc\")")
	xpanel(5,100)

pwmcnt = PWManager[0].count  // the initial GUIs should not be dismissed
ismenu=0		// determines if electrode is defined


proc restart() { local i
	if (electrodes_present) {
		destroy_elec()
	}

	forall delete_section()

	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	stoprun = 0
	cvode_active(0)
	
	sprint(tstr, "%s.oc", $s1)
	load_file(1, tstr)
}

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