CA1 pyramidal neuron (Migliore et al 1999)

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Accession:2796
Hippocampal CA1 pyramidal neuron model from the paper M.Migliore, D.A Hoffman, J.C. Magee and D. Johnston (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons, J. Comput. Neurosci. 7, 5-15. Instructions are provided in the below README file.Contact michele.migliore@pa.ibf.cnr.it if you have any questions about the implementation of the model.
Reference:
1 . Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7:5-15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I Na,t; I A; I K;
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ca1
README.txt
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3.mod *
nax.mod *
fig_1a.hoc
fig_1c.hoc
mosinit.hoc
n160_mod.nrn *
                            
Hippocampal CA1 pyramidal neuron model from the paper 
M.Migliore, D.A Hoffman, J.C. Magee and D. Johnston 
Role of an A-type K+ conductance in the back-propagation of
action potentials in the dendrites of hippocampal pyramidal neurons
J. Comput. Neurosci. 7, 5-15, 1999.

Different kinetics are used for proximal and distal dendritic 
KA channels, with increasing density with distance from the soma.
The kinetics for the Na conductance includes a gate variable 
for the slow inactivation.

To compile the mod files on a unix system use the command nrnivmodl.
Under Windows use the "mknrndll DOS box" from the NEURON program menu
and follow on-screen instructions.

running the simulation hoc files with the command

nrngui fig_1a.hoc
or
nrngui fig_1c.hoc

will generate the simulations shown in Fig.1A and Fig.1C of the
paper, respectively.

Questions on how to use this model should be directed to
michele.migliore@pa.ibf.cnr.it






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