Sleep-wake transitions in corticothalamic system (Bazhenov et al 2002)

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Accession:28189
The authors investigate the transition between sleep and awake states with intracellular recordings in cats and computational models. The model describes many essential features of slow wave sleep and activated states as well as the transition between them.
Reference:
1 . Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (2002) Model of thalamocortical slow-wave sleep oscillations and transitions to activated States. J Neurosci 22:8691-704 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I K,leak; I M; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Short-term Synaptic Plasticity; Depression; Sleep;
Implementer(s): Bazhenov, Maxim [Bazhenov at Salk.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex V1 L6 pyramidal corticothalamic GLU cell; GabaA; GabaB; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I K,leak; I M; I K,Ca;
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