Short term plasticity of synapses onto V1 layer 2/3 pyramidal neuron (Varela et al 1997)

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Accession:3264
This archive contains 3 mod files for NEURON that implement the short term synaptic plasticity model described in Varela, J.A., Sen, K., Gibson, J., Fost, J., Abbott, L.R., and Nelson, S.B.. A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. Journal of Neuroscience 17:7926-7940, 1997. Contact ted.carnevale@yale.edu if you have questions about this implementation of the model.
Reference:
1 . Varela JA, Sen K, Gibson J, Fost J, Abbott LF, Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. J Neurosci 17:7926-40 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal intratelencephalic L2-5 cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neocortex V1 pyramidal intratelencephalic L2-5 cell; AMPA; I Na,t; I K; Glutamate;
Implementations of short-term synaptic plasticity for NEURON.

This archive contains 3 mod files that implement the short term 
synaptic plasticity model described in
  Varela, J.A., Sen, K., Gibson, J., Fost, J., Abbott, L.R., 
  and Nelson, S.B.. 
  A quantitative description of short-term plasticity at 
  excitatory synapses in layer 2/3 of rat primary visual cortex.
  Journal of Neuroscience 17:7926-7940, 1997.

fdsintf.mod is an integrate & fire cell.

fdsexpsn.mod and fdsexp2s.mod are double-exponential 
conductance-change mechanisms based on ExpSyn and Exp2Syn.

NOTES:  

1.  The important parts of this package of files are the 
synaptic mechanisms, not the "cells."  The synaptic mechanisms
are reusable in models of artificial and biophysical neurons.  
The "cells," however, are only the remotest abstractions of a 
V1 layer 2/3 pyramidal neuron.  The "integrate and fire cell" 
is not a specific representation of any particular neuron, 
and the "biophysical neurons" are just single compartments 
that serve as hosts for the conductance change synaptic 
mechanisms.

2.  For information about NEURON's model description language 
NMODL and how to compile mod files see the Documentation 
page at NEURON's WWW site ( http://www.neuron.yale.edu/ ), 
especially the FAQ link on that page.
 
Updated 20110810 by NTC for compatibility with recent versions 
of NEURON.

Contact ted.carnevale@yale.edu if you have questions about 
this implementation of the model described by Varela et al..

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