Action potential initiation in the olfactory mitral cell (Shen et al 1999)

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Accession:3342
Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact Michael.Hines@yale.edu if you have any questions about the implementation of the model.
Reference:
1 . Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I K; I Sodium; I Potassium;
// beginning of two electrode mitral cell simulations
load_file("noload.hoc")
load_file("mulfit.hoc")
xopen("mitral.hoc")
xopen("memb.hoc")
xopen("elec1.hoc")

cut=0

/* take into account new initialseg style
proc nahigh(){ forsec axon gbar_na = 10000*$1
	if (cut > 0) initialseg.gbar_na(0:cut) = soma.gbar_na:soma.gbar_na
}
proc kdhigh(){ forsec axon gbar_kd= 1000*$1
	if (cut > 0) initialseg.gbar_kd(0:cut) = soma.gbar_kd:soma.gbar_kd
}
proc nalow(){ forsec somden gbar_na = 10*$1
	if (cut > 0) initialseg.gbar_na(0:cut) = soma.gbar_na:soma.gbar_na
}
proc kdlow(){ forsec somden gbar_kd = 100*$1
	if (cut > 0) initialseg.gbar_kd(0:cut) = soma.gbar_kd:soma.gbar_kd
}
*/

objref sestim, pestim
se.electrode sestim = new IClamp(.5)
pe.electrode pestim = new IClamp(.5)
sestim.del = 1
sestim.dur = 10
pestim.del = 1
pestim.dur = 10

xopen("mainpan.ses")
xopen("data_in.hoc")



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