Action potential initiation in the olfactory mitral cell (Shen et al 1999)

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Accession:3342
Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact Michael.Hines@yale.edu if you have any questions about the implementation of the model.
Reference:
1 . Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I K; I Sodium; I Potassium;
create soma, priden[2], secden[2], tuftden[2], hillock, initialseg[2]
nmyelin = 5
create node[nmyelin], myelin[nmyelin]

objref dendritic, somatic, tuft, second, somden, axon, sad

dendritic = new SectionList()
forsec "den" dendritic.append()

somatic = new SectionList()
soma somatic.append
hillock somatic.append

tuft = new SectionList()
forsec "tuftden" tuft.append

second = new SectionList()
forsec "secden" second.append

somden = new SectionList()
forsec somatic somden.append()
forsec dendritic somden.append()

axon = new SectionList()
forsec "node" axon.append()
initialseg[0] somden.append()
initialseg[1] axon.append()

sad = new SectionList()
forsec somden sad.append()
forsec axon sad.append()

access soma

proc topol() {local i
	connect secden[0](0), soma(.5)
	connect secden[1](0), soma(.5)
	connect priden[0](0), soma(1)
	connect priden[1](0), priden[0](1) // this junction for electrode
	for i=0, 1 connect tuftden[i](0), priden[1](1)

	connect hillock(0), soma(0)
	connect initialseg[0](0), hillock(1)
	connect initialseg[1](0), initialseg[0](1) // for cut
	connect myelin[0](0), initialseg[1](1)
	for i=0, nmyelin-1 {
		connect node[i](0), myelin[i](1)
		if (i == nmyelin-1) break
		connect myelin[i+1](0), node[i](1)
	}
}

proc segments() {local i
	soma.nseg= 1
	priden[0].nseg = 8
	priden[1].nseg = 2
	forsec "tuft" nseg = 3
	forsec "secden" nseg = 5
	initialseg[0].nseg = 1
	initialseg[1].nseg = 5
	hillock.nseg = 1
	forsec "myelin" nseg=3
}

proc geometry() {local i
	soma { L = 25  diam = 20 }
	priden[0] { L = .8*370  diam=3.5 }
	priden[1] { L = .2*370  diam=3.5 }
	forsec "tuftden" { L=350  diam=2.1 }
	forsec "secden" { L=500  diam=3.4 }
	initialseg[0] { L=.01*20  diam=1.5 }
	initialseg[1] { L=.99*20  diam=1.5 }
	hillock { L=5  diam(0:1) = soma.diam(0) : initialseg.diam(0) }
	forsec "node" { L=1 diam=1 }
	forsec "myelin" { L=1000  diam=1.5 }
	define_shape()
}
	
topol()
segments()
geometry()


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