Action potential initiation in the olfactory mitral cell (Shen et al 1999)

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Accession:3342
Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact Michael.Hines@yale.edu if you have any questions about the implementation of the model.
Reference:
1 . Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I K; I Sodium; I Potassium;
//Wei's two electrodes expriments show active channels in the
//distal portion  of the primary dendrite. This set up a hotspot there.
//using Zachs na and k channels with density similarities to his paper

proc memb() {
	forall {insert pas}
	forall {insert na  insert kd}

	celsius = 23

	forall {
		cm = 1.2
		Ra = 70
		g_pas = 1/30000
		e_pas = -65
		ek = -90
		ena = 60
	}

	forsec "myelin" {
		cm = 0.012
		g_pas = 1/100000
		gbar_na = 0
		gbar_kd = 0
	}
	
	forsec axon {
	        g_pas = 1/1000
	        gbar_na = 10115
	        gbar_kd = 100
	}
}

memb()


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