Thalamocortical and Thalamic Reticular Network (Destexhe et al 1996)

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Accession:3343
NEURON model of oscillations in networks of thalamocortical and thalamic reticular neurons in the ferret. (more applications for a model quantitatively identical to previous DLGN model; updated for NEURON v4 and above)
Reference:
1 . Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76:2049-70 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell;
Channel(s): I Na,t; I T low threshold; I K,leak; I h;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Spatio-temporal Activity Patterns; Sleep; Calcium dynamics; Spindles;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; GabaA; GabaB; AMPA; I Na,t; I T low threshold; I K,leak; I h;
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DLGN_NEW
README
ampa.mod
cadecay.mod *
gabaa.mod
gabab.mod
HH2.mod *
Ih.mod *
IT.mod *
IT2.mod *
kleak.mod *
Fbic.oc
FbicL.oc
Fdelta.oc
FdeltaL.oc
Fspin.oc
FspinL.oc
mosinit.hoc *
RE.tem
rundemo.hoc
TC.tem
                            
//----------------------------------------------------------------------------
//  define a panel to run the different demos
//----------------------------------------------------------------------------

proc make_demopanel() {
	xpanel("Simulations of thalamic oscillations")
	xbutton("Spindle oscillations - short run","restart(\"Fspin\")")
	xbutton("Spindle oscillations - long run","restart(\"FspinL\")")
        xbutton("Bicuculline-induced oscillations - short run","restart(\"Fbic\")")
	xbutton("Bicuculline-induced oscillations - long run","restart(\"FbicL\")")
	xbutton("Delta oscillations - short run","restart(\"Fdelta\")")
	xbutton("Delta oscillations - long run","restart(\"FdeltaL\")")
	xpanel()
}

make_demopanel()

ismenu=0

load_file("nrngui.hoc")

strdef tstr

objref El

electrodes_present=0	// after electrodes are created they must be
			// destroyed if simulation restarted

proc destroy_elec() {
	execute("objref stim, vc",El)
}

pwmcnt = PWManager[0].count  // the initial GUIs should not be dismissed
ismenu=0		// determines if electrode is defined

proc restart() { local i
	if (electrodes_present) {
		destroy_elec()
	}

	forall delete_section()

	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
	stoprun = 0
	cvode_active(0)

	ismenu=0
	
	sprint(tstr, "%s.oc", $s1)
	load_file(1, tstr)
}

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