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Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)
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Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K+ current (IK,A), sustained Ca2+ current (ICa,S), Ca-dependent K+ current (IK,Ca), and a hyperpolarization-activated inward rectifier current (Ih). In this study,we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. See paper for results and more details.
Cai Y, Baxter DA, Crow T (2003) Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT.
J Comput Neurosci
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Neuron or other electrically excitable cell;
Hermissenda photoreceptor Type B;
I L high threshold;
I A, slow;
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I L high threshold
I A, slow
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