>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>> module's name: B >>
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>----------------------------------------------------------------------->
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
B: > Inactivation function (time constant method) >
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>------------------------------->--------------------------------------->
> > >
> 1 > B = ssB (1) >
> > >
>------------------------------->--------------------------------------->
2 > ssB - B >
-1 >IV< > dB/dt= ------------ (2) >
> tB >
>------------------------------->--------------------------------------->
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
ssB: > Steady state value for activation >
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>----------------------->------------------------------------------------------>
> 1 > 1 >
> xxx.xx >h< > ssB = -------------------- (1) >
> xxx.xx >s< > +- -+ p >
> xxx.xx >p< > | (V-h)/s | >
> > |1 + e | >
> > +- -+ >
> > >
>----------------------->------------------------------------------------------>
2 > 1 - Bn >
.285 >Bn< > ssB = -------------------- + Bn >
> -54.3 >h< > +- -+ p
> 12.1684 >s< > | (V-h)/s | (2) >
-57 >h< > +- -+ p
12 >s< > | (V-h)/s | (2) >
1 >p< > |1 + e | >
> +- -+ >
>----------------------->------------------------------------------------------>
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
tB: > Time constant for activation >
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
>----------------------->------------------------------------------------------>
> > >
> 1 > tB = tx (1)>
> xxxx.xx >tx< > >
>----------------------->------------------------------------------------------>
> 2 > tx -tn >
> 829 >tx< > tB = -------------------- + tn (2)>
> 255.7 >tn< > +- -+ p >
> 24 >h< > | (V-h)/s | >
> 5.2 >s< > |1 + e | >
> 1 >p< > +- -+ >
> > >
>----------------------->------------------------------------------------------>
3 > tx -tn >
> .829 >tx< > tB = ----------------------------------- + tn (3)>
> .256 >tn< > +- -+p1 +- -+p2 >
> -3.40 >h1< > | (V-h1)/s1 | | (V-h2)/s2 | >
> -3 >s1< > |1+e | |1+e | >
> 1 >p1< > +- -+ +- -+ >
> 6.83 >h2< > >
> 12.1 >s2< > >
> 1 >p2< >
>1.0
>0.3
.5 >tx<
0.15 >tn<
-4 >h1<
-3 >s1<
1 >p1<
7 >h2<
12 >s2<
1 >p2< >
>----------------------->------------------------------------------------------>
> > +-- -+ >
> 4 > | 1 - rtn | >
> xxx.xx >tx< > tB = tx | -------------------- + rtn | (4)>
> xxx.xx >rtn< > | +- -+ p | >
> xxx.xx >h< > | | (V-h)/s | | >
> xxx.xx >s< > | |1 + e | | >
> x >p< > | +- -+ | >
> > +-- -+ >
> > >
>----------------------->------------------------------------------------------>
> > +-- -+ >
> 5 > | 1 - rtn | >
> xxx.xx >tx< > tB=tx | ---------------------------------- +rtn | (5)>
> xxx.xx >rtn< > | +- -+p1+- -+p2 | >
> xxx.xx >h1< > | | (V-h1)/s1| | (V-h2)/s2| | >
> xxx.xx >s1< > | |1+e | |1+e | | >
> x >p1< > | +- -+ +- -+ | >
> xxx.xx >h2< > +-- -+ >
> xx.xx >s2< > >
> x >p2< > >
>----------------------->------------------------------------------------------>
> Ligand
> -------
> ssB is the steady-stae value of activation and tB is its time constant.
> h's are half parameters, s's are shape parameters and p's are values of the
exponents.
> Bn is the minimal value of activation.
> tx is the maximal value of the time constant and tn is its minimal value.
> rtn = tn/tx
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