Retinal Ganglion Cell: I-CaN and I-CaL (Benison et al. 2001)

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Accession:3457
NEURON mod files for the CaN and CaL currents from the papers: Huang, S.-J. & Robinson, D.W. (1998). Activation and Inactivation properties of voltage-gated calcium currents in developing cat retinal ganglion cells. Neuroscience 85:239-247 (experimental) and Benison G. Keizer J., Chalupa L.M., Robinson D.W., (2001) J. theor. Biol. 210:187-199 (theoretical).
References:
1 . Benison G, Keizer J, Chalupa LM, Robinson DW (2001) Modeling temporal behavior of postnatal cat retinal ganglion cells. J Theor Biol 210:187-99 [PubMed]
2 . Huang SJ, Robinson DW (1998) Activation and inactivation properties of voltage-gated calcium currents in developing cat retinal ganglion cells. Neuroscience 85:239-47 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion cell;
Channel(s): I L high threshold; I N;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Retina ganglion cell; I L high threshold; I N;
NEURON mod files for the CaN and CaL currents from the papers:
Huang and Robinson Neurosci. 85:239 (1998) (exp.)
Benison et al., J.Theor.Biol. 210:187 (2001) (model).

Running the kinetics.hoc simulation file will show 
the activation and inactivation steady-states, the time constants, 
and a family of curves generated modeling the same protocols 
used for Figs.2C-3A of the experimental paper.
The CaL conductance has been modeled as non-inactivating.

The kinetic parameters used here are from the modeling paper.
They where chosen by the authors  
to fit the time course of the currents obtained from whole-cell 
data in their own laboratory, and are based on the results
presented in the experimental paper.

The peak conductances have been adjusted to give approximately the
same peak currents shown in the experiments.
 
Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui kinetics.hoc

Under Windows using NEURON 5.1:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
kinetics.hoc 
will open the simulation window.

Questions on the model parameters should be directed to the 
authors of the modeling paper.

Questions on how to use this model with NEURON
should be directed to michele.migliore@pa.ibf.cnr.it

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