CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:35358
Fig. 2A and 3 are reproduced in this simulation of Pinsky PF, Rinzel J (1994).
References:
1 . Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [PubMed]
2 . Pinsky PF, Rinzel J (1995) Erratum for Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 2:275-275
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; XPP;
Model Concept(s): Active Dendrites;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; I Na,t; I L high threshold; I K,Ca;
:  $Id: rkq.mod,v 1.14 2004/01/27 20:56:10 billl Exp $ 
TITLE rkq
: Afterhyperpolarization K channel (I_AHP).
: From Traub et. al.  (1991) J. Neurophysiol. 66(2) p635, #1172

UNITS { 
	(mV) = (millivolt) 
	(mA) = (milliamp) 
} 

NEURON { 
	SUFFIX rkq
	USEION k READ ek WRITE ik
	USEION ca READ cai
	RANGE gmax, ik, g, i
}

PARAMETER { 
	gmax = 0.0 	(mho/cm2)
	v		(mV) 
	ek 		(mV)  
	cai		(1)
}
 
ASSIGNED { 
  g i
  ik 		(mA/cm2) 
  alpha beta	(/ms)
}
 
STATE {
	m
}

BREAKPOINT { 
	SOLVE states METHOD cnexp
        g = gmax * m
	i = g * ( v - ek ) 
        ik = i
}
 
INITIAL { 
	rates( cai )
	m = alpha / ( alpha + beta )
	m = 0
}
 
DERIVATIVE states { 
	rates( cai )
	m' = alpha * ( 1 - m ) - beta * m 
}

UNITSOFF 

PROCEDURE rates(chi) { 

  if (0.2e-4*cai < 0.01) {
    alpha = 0.2e-4*cai
  } else {
    alpha = 0.01
  }
  beta = 0.001
}

UNITSON

Loading data, please wait...