Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Stochastic LTP/LTD conditioning of a synapse (Migliore and Lansky 1999)
Download zip file
Help downloading and running models
Protracted presynaptic activity can induce long-term potentiation (LTP) or long-term depression (LTD) of the synaptic strength. However, virtually all the experiments testing how LTP and LTD depend on the conditioning input are carried out with trains of stimuli at constant frequencies, whereas neurons in vivo most likely experience a stochastic variation of interstimulus intervals. We used a computational model of synaptic transmission to test if and to what extent the stochastic fluctuations of an input signal could alter the probability to change the state of a synapse. See paper for conclusions.
Migliore M, Lansky P (1999) Long-term potentiation and depression induced by a stochastic conditioning of a model synapse.
(Click on a link to find other models with that property)
Long-term Synaptic Plasticity;
Migliore, Michele [Michele.Migliore at Yale.edu];
Download the displayed file
Loading data, please wait...