Salamander retinal ganglion cell: ion channels (Fohlmeister, Miller 1997)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:3673
A realistic five (5) channel spiking model reproduces the bursting behavior of tiger salamander ganglion cells in the retina. Please see the readme for more information.
Reference:
1 . Fohlmeister JF, Miller RF (1997) Impulse encoding mechanisms of ganglion cells in the tiger salamander retina. J Neurophysiol 78:1935-47 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion GLU cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Influence of Dendritic Geometry; Detailed Neuronal Models; Calcium dynamics;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Retina ganglion GLU cell; I Na,t; I A; I K; I K,Ca; I Calcium;
/* Currents of each of the 5 channels under voltage clamp
   Fig.1 in Fohlmeister & Miller J. Neurophysiol. 78:1935-1947,1997.
*/
load_proc("nrnmainmenu")

create soma

access soma
L=25
diam=25
nseg=1

insert pas
e_pas=-65
g_pas=.00005
Ra=110

insert spike
//gnabar_spike = 0.05 // table 1 but for fig 1 used default value of 0.04
gkbar_spike = 0.012
gabar_spike = 0.036
gcabar_spike = 0.0022
gkcbar_spike = 0.00005

celsius = 22
ena=35
ek=-75

insert cad
//depth_cad = diam / 2
// to get the fig 1 behavior of slowly increasing calcium concentration
// with constant calcium current over 10 ms. We use...
depth_cad = 3 // (micron)
taur_cad = 10 // (ms)

objectvar VoltageClamp
VoltageClamp=new SEClamp(0.5)
VoltageClamp.dur1=10
VoltageClamp.rs=.01

xopen("current.ses")



Loading data, please wait...