Ephaptic interactions in olfactory nerve (Bokil et al 2001)

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Accession:3676
Bokil, H., Laaris, N., Blinder, K., Ennis, M., and Keller, A. (2001) Ephaptic interactions in the mammalian olfactory system. J. Neurosci. 21:RC173(1-5)
Reference:
1 . Bokil H, Laaris N, Blinder K, Ennis M, Keller A (2001) Ephaptic interactions in the mammalian olfactory system. J Neurosci 21:RC173 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials; Extracellular Fields; Ephaptic coupling; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory receptor neuron;
// This example demonstrates that two effects not discussed in the paper
// can result in slightly greater safety factor. I.e. no ephaptic excitation
// occurs in the model with a ratio of stimulated to unstimulated
// axons of 4.  The first change is to ground the extracellular network over
// a small initial region (we also ground the distal region but that is not
// important here) to simulate axons entering a fascicle. This eliminates
// the large response in axon b due to initiation of the spike in axon a.
// (see the black curve in the lower part of fig 3B.)
// The second change is to increase the temperature so that the hh rate constants
// are three times their value for squid at 6.3degrees. This produces narrower
// axon spikes and thus the time that axon b is stimulated ephaptically
// is somewhat shorter, giving it less time to reach threshold.
// Other effects such as increased threshold of receptor cell axons
// or leaky fascicles could also reduce the ephaptic coupling.

load_file("ephap.hoc")
forall uninsert pas
forall insert hh
load_file("ephap4.ses")
forall nseg*=3
{beta = .05 extcelnet()}
xg(0:.1) = 1:1
xg(.9:1) = 1:1
run()


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