Ephaptic interactions in olfactory nerve (Bokil et al 2001)

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Bokil, H., Laaris, N., Blinder, K., Ennis, M., and Keller, A. (2001) Ephaptic interactions in the mammalian olfactory system. J. Neurosci. 21:RC173(1-5)
1 . Bokil H, Laaris N, Blinder K, Ennis M, Keller A (2001) Ephaptic interactions in the mammalian olfactory system. J Neurosci 21:RC173-RC173 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor neuron;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials; Extracellular Fields; Ephaptic coupling; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory receptor neuron;
// test extracellular and linear circuit extracellular connection
// with simple 2 segment model

create a, b
access a
a { pt3dadd(0,0,0,1) pt3dadd(1,0,0,1) }
b { pt3dadd(0,100,0,1) pt3dadd(1,100,0,1) }

forall {
	nseg = 2
	L = 20000 // 2 cm
	diam = 10000 // 1 cm
	// axial resistance Mohm/cm is  4*Ra/PI/diam^2*1e2
	Ra = 1/(4/PI/diam^2*1e2)
	// so resistance between compartment centers should be 1 MOhm
	print "ri(.9) should be 1MOhm: ", ri(.9)
	insert pas e_pas = 0
	// membrane conductance S/cm2
	g_pas = 1e-6/(area(.9)*1e-8)
	print "(MOhm resistance from compartment center across membrane is ", 1/(g_pas(.1)*area(.9)*1e-2)
	insert extracellular
	xg = g_pas
	xraxial = 1
	g_pas(.1) = 0
print "v(.1)+vext(.1)=", v(.1)+vext(.1)
print "v(.9)+vext(.9)=", v(.9)+vext(.9)
print "vext(.9)=", vext(.9)
print "vext(.1)=", vext(.1)

//now connect a to b via linearmechanism
forall xg = 0
objref gmat, cmat, bvec, e, xl, layer, sl, lm
gmat = new Matrix(2,2)
cmat = new Matrix(2,2,2)
bvec = new Vector(2)
e = new Vector(2)
sl = new SectionList()
xl = new Vector(2)
layer = new Vector(2)
a sl.append()
b sl.append()
proc addg() {
        gmat.x[$1][$1] += $3
        gmat.x[$1][$2] -= $3
        gmat.x[$2][$1] -= $4
        gmat.x[$2][$2] += $4 
addg(0,1,g_pas(.9), g_pas(.9))
lm = new LinearMechanism(cmat, gmat, e, bvec, sl, xl, layer)
print "a.v(.1)+a.vext(.1)=", a.v(.1)+a.vext(.1)
print "a.v(.9)+a.vext(.9)=", a.v(.9)+a.vext(.9)
print "a.vext(.9)=", a.vext(.9)
print "a.vext(.1)=", a.vext(.1)

print "b.vext(.1)=", b.vext(.1)
print "b.vext(.9)=", b.vext(.9)
print "b.v(.9)+b.vext(.9)=", b.v(.9)+b.vext(.9)
print "b.v(.1)+b.vext(.1)=", b.v(.1)+b.vext(.1)

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