Thalamic Relay Neuron: I-h (McCormick, Pape 1990)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:3684
NEURON mod files for the Ih current from the paper: McCormick DA, Pape HC. Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J. Physiol. 1990 431:291-318.
Reference:
1 . McCormick DA, Pape HC (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431:291-318 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; I h;
NEURON mod files for the Ih current from the paper:
McCormick DA, Pape HC.
Properties of a hyperpolarization-activated cation current 
and its role in rhythmic oscillation in thalamic relay neurones.
J. Physiol. 1990 431:291-318.

Running the kinetics.hoc simulation file will show 
the activation steady-state, the time constant, a simple simulation
using a somatic current injection, and a family of curves
generated modeling the same protocol used in the experiments. 

Since the experimental values were not explicitly given in the paper,
the voltage dependence of the time constant for activation and
de-activation (Fig.3A) has been approximated with an arbitrary function
using a temperature of 36C, as in the experiments.
 
Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui kinetics.hoc

Under Windows using NEURON 5.2:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
kinetics.hoc 
will open the simulation window.

Questions on how to use this model should be directed to
michele@pa.ibf.cnr.it

McCormick DA, Pape HC (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431:291-318[PubMed]

References and models cited by this paper

References and models that cite this paper

Anderson WD, Galvan EJ, Mauna JC, Thiels E, Barrionuevo G (2011) Properties and functional implications of Ih in hippocampal area CA3 interneurons Pflugers Arch. 462:895-912 [Journal] [PubMed]

   CA3 Radiatum/Lacunosum-Moleculare interneuron, Ih (Anderson et al. 2011) [Model]

Bal R, Oertel D (2000) Hyperpolarization-activated, mixed-cation current (I(h)) in octopus cells of the mammalian cochlear nucleus. J Neurophysiol 84:806-17 [Journal] [PubMed]

   CN Octopus Cell: Ih current (Bal, Oertel 2000) [Model]

Bazhenov M, Timofeev I, Steriade M, Sejnowski T (2000) Spiking-bursting activity in the thalamic reticular nucleus initiates sequences of spindle oscillations in thalamic networks. J Neurophysiol 84:1076-87 [Journal] [PubMed]

Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (1998) Computational models of thalamocortical augmenting responses. J Neurosci 18:6444-65 [Journal] [PubMed]

   Thalamocortical augmenting response (Bazhenov et al 1998) [Model]

Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (2002) Model of thalamocortical slow-wave sleep oscillations and transitions to activated States. J Neurosci 22:8691-704 [Journal] [PubMed]

   Sleep-wake transitions in corticothalamic system (Bazhenov et al 2002) [Model]

Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2012) Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. J Neurophysiol 107:364-83 [Journal] [PubMed]

Blethyn KL, Hughes SW, Toth TI, Cope DW, Crunelli V (2006) Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro. J. Neurosci. 26(9):2474-2486 [PubMed]

Budde T, Coulon P, Pawlowski M, Meuth P, Kanyshkova T, Japes A, Meuth SG, Pape HC (2008) Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Pflugers Arch 456:1061-73 [Journal] [PubMed]

Chan CS, Shigemoto R, Mercer JN, Surmeier DJ (2004) HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. J Neurosci 24:9921-32 [PubMed]

Chemin J, Monteil A, Perez-Reyes E, Bourinet E, Nargeot J, Lory P (2002) Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. J Physiol 540:3-14 [PubMed]

Chen S, Wang J, Siegelbaum SA (2001) Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol 117:491-504 [PubMed]

Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [Journal] [PubMed]

   Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016) [Model]

Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76:2049-70 [Journal] [PubMed]

   Thalamocortical and Thalamic Reticular Network (Destexhe et al 1996) [Model]

Destexhe A, Contreras D, Sejnowski TJ, Steriade M (1994) A model of spindle rhythmicity in the isolated thalamic reticular nucleus. J Neurophysiol 72:803-18 [Journal] [PubMed]

   Thalamic Reticular Network (Destexhe et al 1994) [Model]

Destexhe A, Contreras D, Steriade M (1998) Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol 79:999-1016 [Journal] [PubMed]

   Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001) [Model]

Destexhe A, McCormick DA, Sejnowski TJ (1993) A model for 8-10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophys J 65:2473-7 [Journal] [PubMed]

Destexhe A, Sejnowski TJ (2003) Interactions between membrane conductances underlying thalamocortical slow-wave oscillations. Physiol Rev 83:1401-53 [PubMed]

Doiron B, Noonan L, Lemon N, Turner RW (2003) Persistent Na+ current modifies burst discharge by regulating conditional backpropagation of dendritic spikes. J Neurophysiol 89:324-37 [Journal] [PubMed]

Gabbiani F, Midtgaard J, Knopfel T (1994) Synaptic integration in a model of cerebellar granule cells. J Neurophysiol 72:999-1009 [Journal] [PubMed]

   Synaptic integration in a model of granule cells (Gabbiani et al 1994) [Model]

Hadipour-Niktarash A (2006) A computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus. J Comput Neurosci 20:299-320 [Journal] [PubMed]

   Thalamic transformation of pallidal input (Hadipour-Niktarash 2006) [Model]

Halnes G, Augustinaite S, Heggelund P, Einevoll GT, Migliore M (2011) A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus PLoS Comp. Biol. 7(9):e1002160 [Journal] [PubMed]

   [3 reconstructed morphologies on NeuroMorpho.Org]
   A multi-compartment model for interneurons in the dLGN (Halnes et al. 2011) [Model]

Hausser M, Monsivais P (2003) Less means more: inhibition of spontaneous firing triggers persistent increases in excitability. Neuron 40:449-51 [PubMed]

Hynna KM, Boahen K (2007) Thermodynamically equivalent silicon models of voltage-dependent ion channels. Neural Comput 19:327-50 [PubMed]

Jones SR, Pinto DJ, Kaper TJ, Kopell N (2001) Alpha-frequency rhythms desynchronize over long cortical distances: a modeling study. J Comput Neurosci 9:271-91 [Journal] [PubMed]

Kole MH, Hallermann S, Stuart GJ (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. J Neurosci 26:1677-87 [Journal] [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]
   Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006) [Model]

Kopp-Scheinpflug C, Tozer AJB, Robinson SW,Tempel BL, Hennig MH, Forsythe ID (2011) The Sound of Silence: ionic mechanisms encoding sound termination Neuron 71(5):911-925 [Journal]

   Superior paraolivary nucleus neuron (Kopp-Scheinpflug et al. 2011) [Model]

Lytton WW, Contreras D, Destexhe A, Steriade M (1997) Dynamic interactions determine partial thalamic quiescence in a computer network model of spike-and-wave seizures. J Neurophysiol 77:1679-96 [Journal] [PubMed]

   Thalamic quiescence of spike and wave seizures (Lytton et al 1997) [Model]

Lytton WW, Destexhe A, Sejnowski TJ (1996) Control of slow oscillations in the thalamocortical neuron: a computer model. Neuroscience 70:673-84 [PubMed]

Lytton WW, Sejnowski TJ (1992) Computer model of ethosuximide's effect on a thalamic neuron. Ann Neurol 32:131-9 [PubMed]

Meuth SG, Kanyshkova T, Meuth P, Landgraf P, Munsch T, Ludwig A, Hofmann F, Pape HC, Budde T (2006) Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels. J Neurophysiol 96:1517-29 [Journal] [PubMed]

Migliore M, Shepherd GM (2002) Emerging rules for the distributions of active dendritic conductances. Nature Review Neuroscience 3:362-70 [Journal] [PubMed]

   Modulation of temporal integration window (Migliore, Shepherd 2002) [Model]

Mukherjee P, Kaplan E (1995) Dynamics of neurons in the cat lateral geniculate nucleus: in vivo electrophysiology and computational modeling. J Neurophysiol 74:1222-43 [Journal] [PubMed]

Niktarash AH (2003) Transmission of the Subthalamic Nucleus Oscillatory Activity to the Cortex: A Computational Approach Journal of Computational Neuroscience 15:223-232 [Journal]

Niktarash AH (2006) A computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus J Comput Neurosci 20:299-320 [Journal]

Orio P, Parra A, Madrid R, Gonzalez O, Belmonte C, Viana F (2012) Role of Ih in the firing pattern of mammalian cold thermoreceptor endings J Neurophysiol 108(11):3009-23 [Journal] [PubMed]

   Role of Ih in firing patterns of cold thermoreceptors (Orio et al., 2012) [Model]

Perreault MC, Raastad M (2006) Contribution of morphology and membrane resistance to integration of fast synaptic signals in two thalamic cell types. J Physiol 577:205-220 [PubMed]

Sanchez E, Barro S, Marino J, Canedo A (2003) A computational model of cuneothalamic projection neurons. Network 14:211-31 [PubMed]

Smith GD, Cox CL, Sherman SM, Rinzel J (2000) Fourier analysis of sinusoidally driven thalamocortical relay neurons and a minimal integrate-and-fire-or-burst model. J Neurophysiol 83:588-610 [Journal] [PubMed]

Surkis A, Peskin CS, Tranchina D, Leonard CS (1998) Recovery of cable properties through active and passive modeling of subthreshold membrane responses from laterodorsal tegmental neurons. J Neurophysiol 80:2593-607 [Journal] [PubMed]

Wang XJ (1994) Multiple dynamical modes of thalamic relay neurons: rhythmic bursting and intermittent phase-locking. Neuroscience 59(1):21-31 [Journal] [PubMed]

   Multiple dynamical modes of thalamic relay neurons (Wang XJ 1994) [Model]

Wang XJ, Rinzel J, Rogawski MA (1991) A model of the T-type calcium current and the low-threshold spike in thalamic neurons. J Neurophysiol 66:839-50 [Journal] [PubMed]

   T-type Ca current in thalamic neurons (Wang et al 1991) [Model]

Williams SR, Christensen SR, Stuart GJ, Hausser M (2002) Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro. J Physiol 539:469-83 [PubMed]

Winograd M, Destexhe A, Sanchez-Vives MV (2008) Hyperpolarization-activated graded persistent activity in the prefrontal cortex. Proc Natl Acad Sci U S A 105:7298-303 [Journal] [PubMed]

   Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008) [Model]
   Hodgkin-Huxley model of persistent activity in PFC neurons (Winograd et al. 2008) (NEURON python) [Model]

Zhu JJ, Lytton WW, Xue JT, Uhlrich DJ (1999) An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. J Neurophysiol 81:702-11 [Journal] [PubMed]

   Thalamic interneuron multicompartment model (Zhu et al. 1999) [Model]

Zhu JJ, Uhlrich DJ, Lytton WW (1999) Burst firing in identified rat geniculate interneurons. Neuroscience 91:1445-60 [Journal] [PubMed]

   Thalamic interneuron multicompartment model (Zhu et al. 1999) [Model]

Zhu JJ, Uhlrich DJ, Lytton WW (1999) Properties of a hyperpolarization-activated cation current in interneurons in the rat lateral geniculate nucleus. Neuroscience 92:445-57 [PubMed]

(46 refs)