Thalamocortical augmenting response (Bazhenov et al 1998)

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Accession:37819
In the cortical model, augmenting responses were more powerful in the "input" layer compared with those in the "output" layer. Cortical stimulation of the network model produced augmenting responses in cortical neurons in distant cortical areas through corticothalamocortical loops and low-threshold intrathalamic augmentation. ... The predictions of the model were compared with in vivo recordings from neurons in cortical area 4 and thalamic ventrolateral nucleus of anesthetized cats. The known intrinsic properties of thalamic cells and thalamocortical interconnections can account for the basic properties of cortical augmenting responses. See reference for details. NEURON implementation note: cortical SU cells are getting slightly too little stimulation - reason unknown.
Reference:
1 . Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (1998) Computational models of thalamocortical augmenting responses. J Neurosci 18:6444-65 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; Neocortex V1 pyramidal corticothalamic L6 cell;
Channel(s): I Na,t; I T low threshold; I A; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Synaptic Integration;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; Neocortex V1 pyramidal corticothalamic L6 cell; GabaA; GabaB; AMPA; I Na,t; I T low threshold; I A; I K,Ca; Gaba; Glutamate;
: $Id: cadecay.mod,v 1.4 2002/11/08 15:42:37 billl Exp $
TITLE Fast mechanism for submembranal Ca++ concentration (cai)
:
: Takes into account:
:
:	- increase of cai due to calcium currents
:	- extrusion of calcium with a simple first order equation
:
: This mechanism is compatible with the calcium pump "cad" and has the 
: same name and parameters; however the parameters specific to the pump
: are dummy here.
:
: Parameters:
:
:	- depth: depth of the shell just beneath the membran (in um)
:	- cainf: equilibrium concentration of calcium (2e-4 mM)
:	- taur: time constant of calcium extrusion (must be fast)
:	- kt,kd: dummy parameters
:
: Written by Alain Destexhe, Salk Institute, 1995
:

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
  SUFFIX cadad
  USEION ca READ ica, cai WRITE cai
  RANGE depth,kt,kd,cainf,taur
}

UNITS {
  (molar) = (1/liter)			: moles do not appear in units
  (mM)	= (millimolar)
  (um)	= (micron)
  (mA)	= (milliamp)
  (msM)	= (ms mM)
}

CONSTANT {
  FARADAY = 96489		(coul)		: moles do not appear in units
  :	FARADAY = 96.489	(k-coul)	: moles do not appear in units
}

PARAMETER {
  depth	= 1	(um)		: depth of shell
  taur	= 5	(ms)		: rate of calcium removal
  cainf	= 2.4e-4	(mM)
  kt	= 0	(mM/ms)		: dummy
  kd	= 0	(mM)		: dummy
}

STATE {
  cai		(mM) 
}

INITIAL {
  cai = cainf
}

ASSIGNED {
  ica		(mA/cm2)
  drive_channel	(mM/ms)
}
	
BREAKPOINT {
  SOLVE state METHOD derivimplicit
}

DERIVATIVE state { 
  drive_channel =  - (10000) * ica / (2 * FARADAY * depth)
  if (drive_channel <= 0.) { drive_channel = 0. }	: cannot pump inward
  cai' = drive_channel + (cainf-cai)/taur
}


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