Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
objectvar b
b = new VBox()
b.intercept(1)


xpanel("",1)
xlabel("The Virtual Human Atrial Cell is assembled for NEURON  by I Jacobson")
xlabel("AstraZeneca R & D, Mölndal Sweden ")
xlabel ("emailaddress ingemar.jacobson@astrazeneca.com")
xlabel("The model is based on the paper by Courtemanche et al")
xlabel(" Am J Physiol 1998 275(Heart Circ Physiol 44):H301-H321 and conductance values ") 
xlabel(" are adjusted to give appropriate current densities. Pumps, exchangers and an additional")
xlabel("electroneutral ion accumulation mechanism are sat") 
xlabel(" so that ion concentrations are stable at a pacing rate of 1 Hz.")
xlabel("The kinetics of IKur is modified to fit data of Feng etal Am J Physiol 1998 275(Heart Circ Physiol 44):H1717-H1725.")
xlabel("The possibility to include a nonspecific cation-current with kinetics similar to IKur is also given in the IKur mechanism")
xlabel("For the intracellular Ca dynamics to work the mechanisms Cadynam, ca_jsr, Ca_jsracc")
xlabel("and ca_nsracc have to be inserted. For simulation of intracellular Na+-ion and K+-ion changes") 
xlabel("the mechanisms Na_acc and K_acc have to be inserted.")
xlabel("The model is free to use provided acknowledgement is given to the developers of NEURON")
xlabel("nseg = 1")

xlabel("L=100 um")

xlabel("diam=16 um", 0, 0 )

xlabel("2 uF/cm^2", 1,"", 0, 0 )
xlabel("Vi - intracellular volume 13668um^3", 1,"", 0, 0 )

xlabel("SR -sarcoplasmatic reticulum, ", 1,"", 0, 0 )
xlabel("JSR - junctional SR - SR release compartment", 1,"", 0, 0 )
xlabel("Vrel - SR release compartment volume  96.48um^3", 1,"", 0, 0 )
xlabel("cri - calcium ion conc. in JSR", 1,"", 0, 0 )
xlabel("icr - calcium release current from JSR", 1,"", 0, 0 )
xlabel("krel - Max. release rate for icr 30mse-1", 1,"", 0, 0 )

xlabel("NSR - network SR - SR uptake compartment", 1,"", 0, 0 )
xlabel("Vup - SR uptake compartment volume  1109.52um^3", 1,"", 0, 0 )
xlabel("cui - calcium ion conc. in NSR", 1,"", 0, 0 )
xlabel("cupmax - Max. Ca2+ conc. in uptake compartment 15mM", 1,"", 0, 0 )
xlabel("Iupmax - Max. uptake Ca2+ current (Iup) by NSR 0.005 mM/ms", 1,"", 0, 0 )
xlabel("Kup - [Ca2+]i half-saturation constant for Iup 0.00092mM", 1,"", 0, 0 )



xlabel("Trpn - Total troponin conc. in myoplasm  0.07mM", 1,"", 0, 0 )

xlabel("Kmtrpn - [Ca2+]i half-saturation constant for troponin 0.0005mM", 1,"", 0, 0 )

xlabel("Cmdn - Total calmodulin conc. in myoplasma 0.05 mM ", 1,"", 0, 0 )

xlabel("Kmcmdn - [Ca2+]i half-saturation constant for calmodulin 0.00238mM", 1,"", 0, 0 )

xlabel("Csqn - Total calsequesterin conc. in SR release compartment 10mM", 1,"", 0, 0 )

xlabel("Kmcsqn - [Ca2+]JSR (cri) half-saturation constant for calsequesterin 0.8mM ", 1,"", 0, 0 )

xlabel("IpCamax - Max. Ca2+ pump current (IpCa) 0.00055mA/cm2", 1,"", 0, 0 )

xlabel("gCaL - Max ICaL conductance 0.248mS/cm2", 1,"", 0, 0 )

xlabel("gK1 - Max. IK1 conductance 0.1567mS/cm2", 1,"", 0, 0 )

xlabel("gKr - Max. IKr conductance 0.0588mS/cm2", 1,"", 0, 0 )

xlabel("gKs - Max. IKs conductance 0.258mS/cm2", 1,"", 0, 0 )

xlabel("gKur - Max. IKur conductance 0.13195mS/cm2", 1,"", 0, 0 )

xlabel("gnonspec - Max nonspecific Ication conductance 0 mS/cm2", 1,"", 0, 0 )

xlabel("gnabar - Max INa conductance 15.6 mS/cm2", 1,"", 0, 0 )

xlabel("gbNa - Max. Ibackground (Na) conductance 1.34e-3mS/cm2", 1,"", 0, 0 )

xlabel("gbCa - Max. Ibackground (Ca2+)conductance 2.26e-3mS/cm2", 1,"", 0, 0 )

xlabel("gto - Max. Ito conductance 0.33 mS/cm2", 1,"", 0, 0 )

xlabel("Kneutral - electroneutral K+ - accumulation 3e-5mA/cm2", 1,"", 0, 0 )

xlabel("ImaxNax - Max Ca2+/Na+ exchange current (INaCa) 3.5mA/cm2 ", 1,"", 0, 0 )

xlabel("KnNacx - [Na+]o half-saturation constant for INaCa 87.5 mM", 1,"", 0, 0 )

xlabel("KcNacx - [Ca2+]o half-saturation constant for INaCa 1.38 mM", 1,"", 0, 0 )

xlabel("Naneutral - electroneutral Na+ - accumulation 3.5e-5 mA/cm2", 1,"", 0, 0 )

xlabel("INaKmax - Max. Na+/K+-pump current (INaK) 0.00219 mA/cm2", 1,"", 0, 0 )

xlabel("Kmnai - [Na+]i half-saturation constant for InaK 10mM", 1,"", 0, 0 )

xlabel("Kmko - [K+]o half-saturation constant for InaK 1.5mM", 1,"", 0, 0 )
xlabel("Tauct - scaling factor activation ", 1,"", 0, 0 )
xlabel("Tauinactf - scaling factor fast inactivation ", 1,"", 0, 0 )
xlabel("Tauinacts - scaling factor slow inactivation ", 1,"", 0, 0 )
xlabel("")
xpanel()



b.intercept(0)
b.map("name",200, 300, 400, 500)
xpanel("About model")
xbutton("Info ", "p()")
xpanel()

proc p() {  
           print b.dialog("")
}


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