Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
NEURON { SUFFIX ibackg : cardiac (atrial) background currents from Courtemanche et al Am J Physiol 1998 275:H301
	USEION na READ ena WRITE ina
	USEION ca READ eca WRITE ica
	RANGE gbNa, gbCa
	GLOBAL dummy : prevent vectorization for use with CVODE
}

UNITS { (mV) = (millivolt)  
	(mA) = (milliamp) 
	(mM) = (milli/liter) 
	
}

PARAMETER {
	gbNa =  0.001348e-3  (S/cm2)  <0,1e9>
	gbCa =  0.00226e-3  (S/cm2)    <0,1e9>
}

ASSIGNED {
	celsius (degC)
	v (mV) 
	ina (mA/cm2)  
	ica (mA/cm2)
	ena (mV)
	eca (mV)
	dummy
}

BREAKPOINT {
	
	ina = gbNa*(v - ena)

	ica = gbCa*(v - eca)
}


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