Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
TITLE Potassium ion accumulation
: Intracellular potassium ion accumulation 

NEURON {
	SUFFIX K_acc
	USEION k READ ki, ik WRITE ki
	RANGE Vi, Kneutral: electroneutral K accumulation
}

UNITS {
	
	(mV) = (millivolt)
	(mM) = (milli/liter)
	(mA) = (milliamp)
	F = (faraday) (coulombs)
}

PARAMETER {

	Vi = 13668e-12 (cm3)
	ik 	(mA/cm2)
        Kneutral=3e-5 (mA/cm2) <0,1e6>
}

STATE {
	ki START 141.13	(mM)
	
}

LOCAL ViF
INITIAL {
	VERBATIM

	ki = _ion_ki;
	
	ENDVERBATIM
	ViF = Vi*F*2e4
}

BREAKPOINT {
	SOLVE state METHOD derivimplicit
}

DERIVATIVE state {
	ki' = -(ik-Kneutral) /(ViF)
}
	

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