Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium;
TITLE sodium calcium exchange
: taken from Courtemanche et al Am J Physiol 1998 275:H301

NEURON {
	SUFFIX NaCaex
	USEION ca READ cao, cai WRITE ica
	USEION na READ nao, nai WRITE ina
	RANGE ImaxNax, ica, ina , KnNacx, KcNacx, inacx
	GLOBAL dummy : prevent vectorization for use with CVODE
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
F = (faraday) (coulombs)
	R 	= (k-mole)	(joule/degC)
}

PARAMETER {
	ImaxNax = 3.2       (mA/cm2) <0,1e6>
	KnNacx   =  87.5     (mM)   <0,1e6>
	KcNacx   =  1.38     (mM)   <0,1e6>
}

ASSIGNED {
	celsius (degC)
	v (mV)
	ica (mA/cm2)
	ina (mA/cm2)
	cao (mM)
        cai (mM)
	nao (mM)
	nai (mM)
	inacx (mA/cm2) 
	dummy
}


BREAKPOINT { LOCAL q10, Kqa, KB, k

	k = R*(celsius + 273.14)/(F*1e-3)
		q10 = 3^((celsius - 37)/10 (degC))
	Kqa = exp(0.35*v/k)
	KB = exp( - 0.65*v/k)
			
	inacx = q10*ImaxNax*(Kqa*nai^3*cao-KB*nao^3*cai)/((KnNacx^3 + nao^3)*(KcNacx + cao)*(1 + 0.1*KB))
	ina =  3*inacx
	ica = -2*inacx
}

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