Spinal Motor Neuron (Dodge, Cooley 1973)

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Accession:3805
"The excitability of various regions of the spinal motorneuron can be specified by solving the partial differential equation of a nerve fiber whose diameter and membrane properties vary with distance. For our model geometrical factors for the myelinated axon, initial segment and cell body were derived from anatomical measurements, the dendritic tree was represented by its equivalent cylinder, and the current-voltage relations of the membrane were described by a modification of the Hodgkin-Huxley model that fits voltage-clamp data from the motorneuron. ..."
Reference:
1 . Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord motor neuron; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Active Dendrites; Tutorial/Teaching; Axonal Action Potentials; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Spinal cord motor neuron; I Na,t; I K;
Dodge & Cooley (1973) "Action Potential of the Motorneuron"    
IBM J. Res. Develop. May 219--229

The example simulations produce results similar to those seen in
Figures 3, 5, 6, 7, and 8. Differences may be due to details of
antidromic stimulation not specified in the paper.

This example was prepared by Michael Hines.


Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29

References and models cited by this paper

References and models that cite this paper

Balbi P, Martinoia S, Massobrio P (2015) Axon-somatic back-propagation in detailed models of spinal alpha motoneurons Front. Comput. Neurosci. 9:15 [Journal]

   Axon-somatic back-propagation in a detailed model of cat spinal motoneuron (Balbi et al, 2015) [Model]

Balbi P, Massobrio P, Hellgren-Kotaleski J (2017) A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms PLOS Computational Biology 13(9):e1005737 [Journal] [PubMed]

   A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017) [Model]

Borst A, Haag J (1996) The intrinsic electrophysiological characteristics of fly lobula plate tangential cells: I. Passive membrane properties. J Comput Neurosci 3:313-36 [Journal] [PubMed]

   [11 reconstructed morphologies on NeuroMorpho.Org]
   Fly lobular plate VS cell (Borst and Haag 1996, et al. 1997, et al. 1999) [Model]

Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nat Neurosci 5:533-8 [PubMed]

Gradwohl G, Grossman Y (2008) Analysis of the interaction between the dendritic conductance density and activated area in modulating alpha-motoneuron EPSP: statistical computer model. Neural Comput 20:1385-410 [Journal] [PubMed]

Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [Journal] [PubMed]

   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [Journal] [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]
   Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008) [Model]

Luscher HR, Larkum ME (1998) Modeling action potential initiation and back-propagation in dendrites of cultured rat motoneurons. J Neurophysiol 80:715-29 [Journal] [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]

   Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]

Meeks JP, Mennerick S (2007) Action potential initiation and propagation in CA3 pyramidal axons. J Neurophysiol 97:3460-72 [PubMed]

Melnick IV, Santos SF, Szokol K, Szucs P, Safronov BV (2004) Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat. J Neurophysiol 91:646-55 [Journal] [PubMed]

   Tonic firing in substantia gelatinosa neurons (Melnick et al 2004) [Model]

Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]

   Site of impulse initiation in a neuron (Moore et al 1983) [Model]

Ramon F, Moore JW, Joyner RW, Westerfield M (1976) Squid giant axons. A model for the neuron soma? Biophys J 16:953-63 [PubMed]

Safronov BV, Wolff M, Vogel W (2000) Excitability of the soma in central nervous system neurons. Biophys J 78:2998-3010 [PubMed]

   Excitability of the soma in central nervous system neurons (Safronov et al 2000) [Model]

Segev I, Rall W (1998) Excitable dendrites and spines: earlier theoretical insights elucidate recent direct observations. Trends Neurosci 21:453-60 [PubMed]

Shepherd GM, Brayton RK (1979) Computer simulation of a dendrodendritic synaptic circuit for self- and lateral-inhibition in the olfactory bulb. Brain Res 175:377-82 [Journal] [PubMed]

   Dendro-dendritic synaptic circuit (Shepherd Brayton 1979) [Model]

Shepherd GM, Brayton RK (1987) Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience 21:151-65 [Journal] [PubMed]

Stasheff SF, Hines M, Wilson WA (1993) Axon terminal hyperexcitability associated with epileptogenesis in vitro. I. Origin of ectopic spikes. J Neurophysiol 70:961-75 [Journal] [PubMed]

Stuart G, Spruston N, Sakmann B, Hausser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]

(19 refs)