Synaptic plasticity: pyramid->pyr and pyr->interneuron (Tsodyks et al 1998)

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Accession:3815
An implementation of a model of short-term synaptic plasticity with NEURON. The model was originally described by Tsodyks et al., who assumed that the synapse acted as a current source, but this implementation treats it as a conductance change. Tsodyks, M., Pawelzik, K., Markram, H. Neural networks with dynamic synapses. Neural Computation 10:821-835, 1998. Tsodyks, M., Uziel, A., Markram, H. Synchrony generation in recurrent networks with frequency-dependent synapses. J. Neurosci. 2000 RC50.
Reference:
1 . Tsodyks M, Pawelzik K, Markram H (1998) Neural networks with dynamic synapses. Neural Comput 10:821-35 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Facilitation; Depression;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  AMPA; Glutamate;
load_file("nrngui.hoc")
load_file("celint70.ses")
load_file("netint70.ses")
load_file("rigint70.ses")

objref vbox
vbox = new VBox()
vbox.intercept(1)	//all following creations go into the "vbox" box
xpanel("Description and Instructions")
xlabel("Synaptic facilitation and early depression at a synapse from a layer V")
xlabel("pyramidal cell onto an inhibitory interneuron.")
xlabel("To run a simulation, click on Init & Run in the RunControl window (above).")
xlabel("=============================")
xlabel("What are all these windows?")
xlabel("The NetReadyCellGUI window was used to specify a model 'interneuron'")
xlabel("that has a synaptic mechanism on it.  To see the parameters that affect")
xlabel("synaptic plasticity, click on Info in the NetReadyCellGUI window and")
xlabel("select the Synapse Types item.")
xlabel("The ArtCellGUI window controls the timing and rate of firing of an")
xlabel("'artificial neuron' whose sole purpose is to activate the synapse.")
xlabel("The NetGUI window (under this one) specifies that an artificial neuron")
xlabel("drives the synaptic mechanism on an interneuron.")
xlabel("For a tutorial on how to use these tools to create your own models,")
xlabel("see the Documentation page at http://www.neuron.yale.edu/")
xpanel()
vbox.intercept(0)	//ends intercept mode 
vbox.map("Description and Instructions", 400, 400, -1, 0)	//draw the box and its contents

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