Synaptic plasticity: pyramid->pyr and pyr->interneuron (Tsodyks et al 1998)

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Accession:3815
An implementation of a model of short-term synaptic plasticity with NEURON. The model was originally described by Tsodyks et al., who assumed that the synapse acted as a current source, but this implementation treats it as a conductance change. Tsodyks, M., Pawelzik, K., Markram, H. Neural networks with dynamic synapses. Neural Computation 10:821-835, 1998. Tsodyks, M., Uziel, A., Markram, H. Synchrony generation in recurrent networks with frequency-dependent synapses. J. Neurosci. 2000 RC50.
Reference:
1 . Tsodyks M, Pawelzik K, Markram H (1998) Neural networks with dynamic synapses. Neural Comput 10:821-35 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Facilitation; Depression;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  AMPA; Glutamate;
load_file("nrngui.hoc")

objref menubox

proc run_fig1a() {
	load_file("initf1a.hoc")
	menubox.unmap()
}

proc run_fig1b() {
	load_file("initf1b.hoc")
	menubox.unmap()
}

proc run_fig1c() {
	load_file("initf1c.hoc")
	menubox.unmap()
}

proc make_demopanel() {
	menubox = new VBox()
	menubox.intercept(1)       //all following creations go into the "vbox" box
	xpanel("Short-term synaptic plasticity")
	xlabel("Models of short-term synaptic plasticity")
	xlabel("Choose one of the following:")
	xbutton("Fig. 1A pyramid-->pyramid (depression)", "run_fig1a()")
	xbutton("Fig. 1B pyramid-->interneuron at 20 Hz (facilitation)", "run_fig1b()")
	xbutton("Fig. 1C pyramid-->interneuron at 70 Hz (facilitation-depression)", "run_fig1c()")
	xpanel()
	menubox.intercept(0)       //ends intercept mode
	menubox.map()              //draw the box and its contents
}

make_demopanel()

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