Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)

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Accession:3817
This package shows single-compartment models of different classes of cortical neurons, such as the "regular-spiking", "fast-spiking" and "bursting" (LTS) neurons. The mechanisms included are the Na+ and K+ currents for generating action potentials (INa, IKd), the T-type calcium current (ICaT), and a slow voltage-dependent K+ current (IM). See http://cns.fmed.ulaval.ca/alain_demos.html
References:
1 . Destexhe A, Contreras D, Steriade M (1998) Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol 79:999-1016 [PubMed]
2 . Destexhe A, Contreras D, Steriade M (2001) LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38:555-563
3 . Destexhe A, Sejnowski TJ (2001) Thalamocortical Assemblies-How Ion Channels, Single Neurons and large-Scale Networks Organize Sleep
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; Neocortex V1 pyramidal corticothalamic L6 cell; GabaA; GabaB; AMPA; Gaba; I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
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cortex
README
cadecay.mod *
hh2.mod *
IM.mod *
IT.mod *
demo_IN_FS.oc
demo_PY_LTS.oc
demo_PY_RS.oc
mosinit.hoc *
rundemo.hoc
sIN_template
sPY_template
sPYr_template
                            
   NEURON DEMO FOR SIMULATING DIFFERENT CLASSES OF CORTICAL NEURONS

                          Alain Destexhe

            CNRS, UNIC (Bat-33), Avenue de la Terrasse,
                 91198 Gif-sur-Yvette, France

                     Destexhe@iaf.cnrs-gif.fr
                    http://cns.iaf.cnrs-gif.fr


This package is running with the NEURON simulation program written by Michael
Hines and available on internet at:
  http://www.neuron.yale.edu

The package contains mechanisms (.mod files) and programs (.oc files) needed to
simulate single-compartment models of cortical neurons.  Details of the
kinetics of currents are given in:

  Destexhe A and Sejnowski TJ.  Thalamocortical Assemblies.
  Oxford University Press, 2001

See also the original paper:

  Destexhe A, Contreras D and Steriade M.  Mechanisms underlying the 
  synchronizing action of corticothalamic feedback through inhibition of 
  thalamic relay cells. J. Neurophysiol. 79: 999-1016, 1998.

  Destexhe A, Contreras D and Steriade M.  LTS cells in cerebral cortex
  and their role in generating spike-and-wave oscillations.   
  Neurocomputing 38: 555-563, 2001.

(see electronic copy at  http://cns.iaf.cnrs-gif.fr)



  PROGRAMS
  ========

demo_PY_RS.oc  : regular-spiking pyramidal neuron
demo_PY_LTS.oc : bursting pyramidal neuron (LTS cell)
demo_IN_FS.oc  : fast-spiking interneuron


  MECHANISMS
  ==========

 HH2.mod		: fast sodium spikes (Na and K currents)
 IM.mod 		: slow voltage-dependent potassium current (IM)
 IT.mod 		: T-type calcium current
 cadecay.mod		: intracellular calcium dynamics


  HOW TO RUN
  ==========

Use autolaunch on modeldb or:

unix platform:

To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using.  Just type "nrnivmodl" to compile the mechanisms
given in the mod files.

Then, execute the main demo program by typing:

  nrngui mosinit.hoc

mswin platform:

  Compile the mechanism (mod) files by using mknrndll.  Then start the simulation
  by clicking on mosinit.hoc in windows explorer.

back to any platform:

Once the menu and graphics interface has appeared, select a simulation from the
"Simulations of cortical cells" window.  Reposition the windows to find the
Run Control window.   Then click on "Init and Run" button to start the simulation...

For more information about how to get NEURON and how to install it, please
refer to the following sites:
  http://www.neuron.yale.edu
  http://www.neuro.duke.edu



For further information, please contact:

Alain Destexhe

CNRS, UNIC (Bat-33), 
Avenue de la Terrasse,
91198 Gif-sur-Yvette, 
France

email: Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr

7/11/2005 Changes added which removes electrode on subsequent simulations.
Note: 3/9/2002 Michael Hines made non-substantive changes to allow the
3 demos to run in the same NEURON process. Thus the original button panel
was replaced by a radio button panel, and any files which should only
be opened once per NEURON launch are now opened via load_file instead
of xopen. Lastly, before the gui for each demo is started the previous
gui is erased with the restart() procedure which was added to
rundemo.hoc

20120109 updated SOLVE method in cadecay.mod to derivimplicit and IM.mod,
IT.mod to cnexp as per
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592

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