Multiple modes of a conditional neural oscillator (Epstein, Marder 1990)

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Accession:42321
We present a model for a conditional bursting neuron consisting of five conductances: Hodgkin-Huxley type time- and voltage-dependent Na+ and K+ conductances, a calcium activated voltage-dependent K+ conductance, a calcium-inhibited time- and voltage-dependent Ca++ conductance, and a leakage Cl- conductance. Different bursting and silent modes and transitions between them are analyzed in the model and compared to bursting modes in experiment. See the paper for details.
Reference:
1 . Epstein IR, Marder E (1990) Multiple modes of a conditional neural oscillator. Biol Cybern 63:25-34 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Chloride; I Na,t; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Bursting; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Chloride; I Na,t; I K; I Sodium; I Calcium; I Potassium;
README.txt

The goal of the present simulation is to implement 
a model published by Epstein & Marder (1990) and 
check the accuracy of SNNAP by comparing SNNAP-
generated results with previously published results.

This subdirectory contains a model originally published
by:

Epstein, I.R. and Marder, E. (1990)  Multiple modes of a 
conditional neural oscillator.  Biol. Cybern.  63: 25-34.

The present model corresponds to the "Model N" of 
Epstein and Marder (1990). The components of the
modeled bursting neuron are illustrated in
Epstein_neu.jpg.  The default simulation is
similar to Fig. 5 of Epstein and Marder (1990).

The results of the SNNAP simulation are illustrated in
Epstein.jpg.

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