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Kinetic NMDA receptor model (Kampa et al 2004)
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This kinetic NMDA receptor model is based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa et al 2004 J Physiol), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. The demo shows the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2. The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor. This model was written by Bjoern Kampa, Canberra, 2004.
Kampa BM, Clements J, Jonas P, Stuart GJ (2004) Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity.
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Neocortex V1 pyramidal corticothalamic L6 cell;
Ion Channel Kinetics;
Long-term Synaptic Plasticity;
Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
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Neocortex V1 pyramidal corticothalamic L6 cell
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Other models using NMDA_Mg.mod:
AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
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Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
STDP depends on dendritic synapse location (Letzkus et al. 2006)
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