Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)

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Accession:50210
The model supports the experimental findings on the effects of postnatal odor deprivation, and shows that a -10mV shift in the Na activation or a reduction in the dendritic length of newborn GC could independently explain the observed increase in excitability.
Reference:
1 . Saghatelyan A,Roux P,Migliore M,Rochefort C,Desmaisons D,Charneau P,Shepherd GM, Lledo PM (2005) Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation. Neuron 46:103-116 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
/
saghatelyan
readme.txt
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanet.mod
gc-occ.hoc
mitral-occ.hoc
modeldb.zip
mosinit.hoc
occlusion.hoc
                            
NEURON mod files from the paper:
Activity-Dependent Adjustments of the Inhibitory Network 
in the Olfactory Bulb Following Early Postnatal Deprivation,
by Saghatelyan, A., Roux, P., Migliore, M., Rochefort, C., Desmaisons,
D., Charneau, P., Shepherd, G.M., and Lledo, P.M. 
Neuron 46:103-116, 2005.

The paper investigates the role of experience in 
sculpting neuronal network in the Olfactory bulb.
It was found that nostril closure decreased the number of
newborn granule cells of the MOB, the complexity of their dendritic arborization,
and spine density. However, due to a compensatory increase in the newborn 
granule cells excitability, the action potential-dependent GABA release was dramatically 
enhanced, counteracting thus the reduction in the spine density and leading to an 
unaltered synchronization of mitral cells firing activity.
The model supports the experimental findings, and shows that a -10mV shift in the
Na activation or a reduction in the dendritic lenght of newborn GC
could independenlty explain the observed increase in excitability. 

The effect is demonstrated here by reproducing the simulations
in Figs.6 and 8 of the paper.
3 simulations can be run for different kind of model setup:
- control conditions 
- shift in the GC Na activation. 
- reduced dendritic length of GC

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui occlusion.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
occlusion.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it



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